Registration Dossier
Registration Dossier
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EC number: 692-065-2 | CAS number: 15708-55-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- This reports evaluates the eye irritating properties of metallic nickel and several widely used nickel(2+) salts. It collects all available information on toxicological properties of those substances, was written and reviewed by experts and thus can be seen as a reliable data source.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report; nickel and nickel compounds
- Author:
- Luxembourg: Office for Official Publications of the European Communities, Rapporteur for the risk assessment of Nickel is Denmark
- Year:
- 2 008
- Bibliographic source:
- EU Risk Assessment Reports, #93, 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- This reports evaluates the eye irritating properties of metallic nickel and several widely used nickel salts. It collects all available information on toxicological properties of those substances, was written and reviewed by experts and thus can be seen as a reliable data source.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nickel sulphate
- EC Number:
- 232-104-9
- EC Name:
- Nickel sulphate
- Cas Number:
- 7786-81-4
- Molecular formula:
- H2O4S.Ni
- IUPAC Name:
- Nickel (II)sulphate
1
- Specific details on test material used for the study:
- The report refers to studies on metallic nickel and several metal salts, e.g. nickel sulphate.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: evaluation of the parameters of several studies
- Basis:
- mean
- Time point:
- other: not stated
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The report concludes that neither nickel nor the evaluated nickel salts are eye irritating due to their chemical properties. For metallic nickel powder a mechanical eye irritation has to be considered.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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