Registration Dossier
Registration Dossier
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EC number: 500-343-0 | CAS number: 157627-92-4 1 - 2.5 moles ethoxylated
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Study was conducted before implementation of GLP.
Test material
- Reference substance name:
- Alcohols, C12-14, ethoxylated, sulfates, sodium salts
- EC Number:
- 500-234-8
- EC Name:
- Alcohols, C12-14, ethoxylated, sulfates, sodium salts
- Cas Number:
- 68891-38-3
- Molecular formula:
- not applicable, UVCB
- IUPAC Name:
- Alcohols, C12-14(even numbered), ethoxylated < 2.5 EO, sulfates, sodium salts
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Kleine weiße Russen, Chbb-SPF
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- n.a.
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.8
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- other: Eye damage 1, H318. Classification according to Regulation (EC) No 1272/2008 (CLP/EU GHS).
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