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Registration Dossier
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EC number: 203-483-8 | CAS number: 107-35-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Salmonella mutagenicity test
- Author:
- Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals
- Year:
- 1 988
- Bibliographic source:
- Environ. MolecMutagen. Vol. 11 (Suppl 12) (1988) 1-158
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Guideline not specified.
- GLP compliance:
- not specified
- Type of assay:
- other: Not specified
Test material
- Reference substance name:
- Taurine
- EC Number:
- 203-483-8
- EC Name:
- Taurine
- Cas Number:
- 107-35-7
- Molecular formula:
- C2H7NO3S
- IUPAC Name:
- 2-aminoethanesulfonic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Method
- Target gene:
- Salmonella typhimurium strains TA100, TA1535, TA97, TA98
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 97
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 1535
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
Results and discussion
Test results
- Species / strain:
- other: S. typhimurium TA 1535, 100, 98 and 97
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Bacterial mutagenicity assay for L-Taurine in Salmonella typhimurium strains TA100, TA1535, TA97, TA98 was negative with or without activation.
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