Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 923-466-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Aquatic toxicity endpoints are based on test data following standard guidelines. All data are therefore considered to be reliable and relevant for the endpoint concerned.
Short-term toxicity to aquatic invertebrates
This data requirement has been waived on the basis that a reliable long-term toxicity study to Daphnia magna is available.
Long-term toxicity to aquatic invertebrates
Chronic toxicity to Daphnia magna has been assessed for one substance that would fall within the NDI category definition: Reaction product of 1,5-naphthylene diisocyanate and cyclohexylamine. A Daphnia reproduction study conducted according to OECD guideline 211 was carried out using a water accommodated fraction at a single nominal loading rate of 100 mg/L, as the test item is poorly soluble. The determined EL50 values, based on parental mortality and reproduction, were >100 mg/L, with a NOELR value of 100 mg/L, the only concentration tested. Based on these results, members of the NDI category are not expected to be toxic to aquatic invertebrates at the limit of solubility.
Toxicity to aquatic algae and cyanobacteria
The effects of one NDI category member on the growth of Pseudokirchneriella subcapitata was investigated. The study used a water accommodated fraction and determined EL50 values of >100 mg/L, with NOELR values of 100 mg/L, for both growth rate and yield, for the test item Reaction product of 1,5-naphthylene diisocyanate and cyclohexylamine.
Based on these result, members of the NDI category are not expected to be toxic to aquatic algae at the limit of solubility.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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