2-amino-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

January - May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Remarks on exposure duration:

Standard exposure duration

Post exposure observation period:

No post-exposure period; last observation at 48 hrs.

Hardness:

250 mg CaCO3/L (2.502 mmol/L)

Test temperature:

20 ± 2°C

pH:

7.8 ± 0.2

Dissolved oxygen:

>= 3 mg/L

Salinity:

<0.5 ppt

Conductivity:

25 mS/m

Nominal and measured concentrations:

100 mg/L (measured concentration)

Reference substance (positive control):

yes

Key result

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

100 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: No toxic effect observed

Validity criteria fulfilled:

yes

Conclusions:

At a limit concentration of 100 mg/L, SP02 was not observed to affect the behaviour or mobility of Daphnia Magna. The NOEC is therefore 100 mg/L.

Executive summary:

At a limit concentration of 100 mg/L, SP02 was not observed to affect the behaviour or mobility of Daphnia Magna. The NOEC is therefore >100 mg/L.

Description of key information

At a limit concentration of 100 mg/L, SP02 was not observed to affect the behaviour or mobility of Daphnia Magna. The NOEC is therefore 100 mg/L.