Registration Dossier
Registration Dossier
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EC number: 224-116-8 | CAS number: 4203-89-8
Endpoint summary
Administrative data
Description of key information
Three acute studies for three trophic levels are available.
The acute fish endpoint is fulfilled using Weight of Evidence. An OECD 236 (FET) study of substance 4203-89-8 gave an LC 50 of > 100 mg/L. It was demonstrated that 4203-89-8 rapidly hydrolyzes (see 5.1.2) to 108-94-1 and 51706-72-0/45011-26-5. The FET result is in line with ECOSAR results for the hydrolysis byproducts (all LC 50 > 100 mg/L).
The acute toxicity of 2 -(1 -oxa-4 -azaspiro[4.5]dec-4 -yl)ethyl methacrylate to invertebrates was determined in an OECD 202 study. In a limit test at 100 mg/L no effects were found and the EC50 is greater than 100 mg/L (nominal). This is equal to a geometric mean measured concentration of 34.6 mg/L cyclohexanone. Initial concentration cyclohexanone was 37.7 mg/L, which is similar to the theoretical maximum amount of 38.7 mg/L that can be formed when 100 mg/L parent substance degrades.
From these results it can be shown that the parent substance was fully hydrolyzed at test start and test animals were exposed to cyclohexanone and 2-[(2-hydroxyethyl)amino]ethyl 2-methylacrylate.
100 mg/L parent substance is equal to 68.4 mg/L 2-[(2-hydroxyethyl)amino]ethyl 2-methylacrylate.
The toxicity of 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate to freshwater algae was determined in an OECD 201 study. The effect of the test item on the growth of Pseudokirchneriella subcapitata has been investigated over a 72 hour period and based on the nominal parent test concentrations gave the following results: 72h-ErC50 = 88 mg/L.
The 100 mg/L nominal test concentration is equal to a geometric mean measured concentration of 36.4 mg/L cyclohexanone. Initial concentration cyclohexanone was 39 mg/L, which is similar to the theoretical maximum amount of 38.7 mg/L that can be formed when 100 mg/L parent substance degrades.
From these results it can be shown that the parent substance was fully hydrolyzed at test start and test animals were exposed to cyclohexanone and2-[(2-hydroxyethyl)amino]ethyl 2-methylacrylate.
The 72 -hErC50 is equal to 60.2 mg/L 2-[(2-hydroxyethyl)amino]ethyl 2-methylacrylate.
The toxicity of 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate to activated sludge was determined in an OECD 209 study under GLP. From the results EC values were calculated. The EC10, EC20, EC50and EC80values of the substance for activated sludge after 3 hours contact time are all >1280 mg/L, the highest concentration tested. 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate is therefore considered not harmful to activated sludge.
Additional information
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