Reaction mass of hydroxyethyl-DETA, DETA and dihydroxyethyl-DETA

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

not applicable

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was conducted prior to GLP and test guidelines, but sufficient data are available for interpretation of results.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1948

Report date:

1948

Materials and methods

Principles of method if other than guideline:

Conducted prior to Guidelines

GLP compliance:

no

Remarks:

Conducted prior to GLPs

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-iminodi(ethylamine)

EC Number:

203-865-4

EC Name:

2,2'-iminodi(ethylamine)

Cas Number:

111-40-0

Molecular formula:

C4H13N3

IUPAC Name:

N-(2-aminoethyl)ethane-1,2-diamine

Details on test material:

Identification number: 550-A-2952.

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

10% dilution of DETA in water

Doses:

Doses not indicated

No. of animals per sex per dose:

Not indicated

Control animals:

no

Results and discussion

Effect levels

Dose descriptor:

LD50

Effect level:

2.33 other: g/kg

Remarks on result:

other: range (2.08 to 2.16)

Clinical signs:

other: No untoward symptoms were noted following the doses, except sluggishness.

Any other information on results incl. tables

Dosages at or above the LD 50 caused severe lung hemorrhage, mottled livers and kidneys and irritation of the stomach and intestines. This acute oral toxicity is roughly equivalent to that of 76% ethylene diamine and somewhat greater than that of triethylene tetramine LD50 4.34 g/kg, and tetraethylene pentamine LD50 3.99 g/kg.

Applicant's summary and conclusion

Conclusions:

The oral LD50 for male albino rats fed a 10% dilution of diethylene triamine in water is 2.33 (2.08 to 2.61) g/kg. It is a moderately toxic compound as judged by its acute oral toxicity for rats.

Executive summary:

Diethyiene triamine, LD50 2.33(2.08 to 2.61) g/kg, is a moderately toxic compound as judged by its acute oral toxicity for rats. It is roughly equivalent in toxicity to the 76% solution of ethylene diamine currently being tested and is somewhat more toxic than triethylene tetramine and tetraethylene pentamine which have LD50 values of 4.34 and 3.99 g/kg respectively.