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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
GLP compliance:
yes
Type of method:
sieving
Remarks:
followed by scanning electron microscopy
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
22.87 µm
Size:
22.87 µm
Remarks on result:
other: Spherical Volume, Median diameter, corresponding to MMAD (Mass Median Aerodynamic Diameter)
Size:
18.67 µm
Remarks on result:
other: Cubical Volume, Median diameter, corresponding to MMAD (Mass Median Aerodynamic Diameter)

Sieve Fraction:

weighted sample: 1.1534 g

weight fraction <100 μm: 0.0511 g

mass fraction <100 μm: 4.43 %

Result: Mass Fraction (calculated)

Sieve Fraction nominal < 100 μm

Mass Fraction (Sieve Fraction < 100 µm)

 Partcle Size  Spherical Volume [%]  Cubical Volume [%]
 <4 μm (respirable)  0.00 %  0.00 %
 4-10 μm (thoracic)  0.64 %  0.83 %
 10-100 μm (inhalable)  99.36 %  99.16 %
 >100 μm  0.00 %  0.00 %
 Median (diameter μm)  22.87 μm  18.67 μm

Conclusion

       Accounting based on the total sample weight
   Particle Size [μm]  Spherical Volume [%]
 Mass Fraction  >100  89.33
 Sieve Fraction  >100  0.00
 Total (>100μm)    89.33
 Sieve Fraction  10-100 (inhalable)  10.60
 Sieve Fraction  4-10 (thoracic)  0.07
 Sieve Fraction  <4 (respirable)  0.00

The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a value of 22.87 µm as spherical particles.

Conclusions:
The MMAD (Mass Median Aerodynamic Diameter < 100 µm) of Anthraquinone-2-sulfonic acid sodium salt has a value of 22.87 µm as spherical particles.
Executive summary:

According to OECD guideline 110 the particle size distribution of Anthraquinone-2-sulfonic acid sodium salt was fractionated by a 100 μm sieve and tested by scanning electron microscopy (SEM). The fraction < 100 μm is gushed to carbon pads and sputtered with gold. The particle classification (mean diameter): 0.4-0.5, 0.5-1.0, 1-2, 2-3, 3-5 and 5-100 μm, additional <0.4 and >100μm is reported. The mass fraction is calculated for spherical and cubical volume in classes of particle diameter <4 μm, 4-10 μm, 10-100 μm and > 100 μm. For the determination of the particle size and the aspect ratio, 4 pictures have been taken by SEM at a magnification of 350 times. The MMAD (Mass Median Aerodynamic Diameter < 100 µm) of Anthraquinone-2-sulfonic acid sodium salt has a value of 22.87 µm as spherical particles. The Spheric Volume of the mass fraction > 100 µm was 89.33 %.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100 µm) of Anthraquinone-2-sulfonic acid sodium salt has a value of 22.87 µm as spherical particles.

Additional information