Sodium 9,10-dihydro-9,10-dioxoanthracene-2-sulphonate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

no

GLP compliance:

yes

Type of method:

sieving

Remarks:

followed by scanning electron microscopy

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Mass median aerodynamic diameter:

22.87 µm

Size:

22.87 µm

Remarks on result:

other: Spherical Volume, Median diameter, corresponding to MMAD (Mass Median Aerodynamic Diameter)

Size:

18.67 µm

Remarks on result:

other: Cubical Volume, Median diameter, corresponding to MMAD (Mass Median Aerodynamic Diameter)

Sieve Fraction:

weighted sample: 1.1534 g

weight fraction <100 μm: 0.0511 g

mass fraction <100 μm: 4.43 %

Result: Mass Fraction (calculated)

Sieve Fraction nominal < 100 μm

Mass Fraction (Sieve Fraction < 100 µm)

Partcle Size	Spherical Volume [%]	Cubical Volume [%]
<4 μm (respirable)	0.00 %	0.00 %
4-10 μm (thoracic)	0.64 %	0.83 %
10-100 μm (inhalable)	99.36 %	99.16 %
>100 μm	0.00 %	0.00 %
Median (diameter μm)	22.87 μm	18.67 μm

Conclusion

Accounting based on the total sample weight
	Particle Size [μm]	Spherical Volume [%]
Mass Fraction	>100	89.33
Sieve Fraction	>100	0.00
Total (>100μm)		89.33
Sieve Fraction	10-100 (inhalable)	10.60
Sieve Fraction	4-10 (thoracic)	0.07
Sieve Fraction	<4 (respirable)	0.00

The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a value of 22.87 µm as spherical particles.

Conclusions:

The MMAD (Mass Median Aerodynamic Diameter < 100 µm) of Anthraquinone-2-sulfonic acid sodium salt has a value of 22.87 µm as spherical particles.

Executive summary:

According to OECD guideline 110 the particle size distribution of Anthraquinone-2-sulfonic acid sodium salt was fractionated by a 100 μm sieve and tested by scanning electron microscopy (SEM). The fraction < 100 μm is gushed to carbon pads and sputtered with gold. The particle classification (mean diameter): 0.4-0.5, 0.5-1.0, 1-2, 2-3, 3-5 and 5-100 μm, additional <0.4 and >100μm is reported. The mass fraction is calculated for spherical and cubical volume in classes of particle diameter <4 μm, 4-10 μm, 10-100 μm and > 100 μm. For the determination of the particle size and the aspect ratio, 4 pictures have been taken by SEM at a magnification of 350 times. The MMAD (Mass Median Aerodynamic Diameter < 100 µm) of Anthraquinone-2-sulfonic acid sodium salt has a value of 22.87 µm as spherical particles. The Spheric Volume of the mass fraction > 100 µm was 89.33 %.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100 µm) of Anthraquinone-2-sulfonic acid sodium salt has a value of 22.87 µm as spherical particles.