Potassium niobate

Repeated dose toxicity: oral

Administrative data

Endpoint:

repeated dose toxicity: oral, other

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1965, July - August

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

The toxicity of Niobium salts

Author:

Downs W.L. et al.

Year:

1965

Bibliographic source:

American Industrial Hygiene Association Journal, 26:4, 337 - 346

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

- Principle of test: To investigate the sub-acute oral toxicity of Potassium Niobate
- Short description of test conditions: - Three groups (same number and sex) were fed diets containing 0, 0.10 and 1 % Potassium Niobate.
- Parameters analysed / observed: Body weight, histopathology of the liver, spleen, and kidney

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium niobate

EC Number:

234-744-4

EC Name:

Potassium niobate

Cas Number:

12030-85-2

Molecular formula:

K.NbO3

IUPAC Name:

niobium(5+) potassium trioxidandiide

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source of test material: Union Carbide Metals Co., Niagara Falls, N.Y.

Test animals

Species:

rat

Sex:

male

Administration / exposure

Route of administration:

oral: feed

Vehicle:

not specified

Details on oral exposure:

DOSING SOLUTIONS: 0, 0.10 and 1.0% Potassium Niobate

Duration of treatment / exposure:

7 weeks

Doses / concentrations

Doses / concentrations 1

Dose / conc.:

1 mg/kg diet

Doses / concentrations 2

Dose / conc.:

10 mg/kg diet

No. of animals per sex per dose:

three groups of 5 males weanling rats each

Control animals:

yes, concurrent no treatment

Examinations

Observations and examinations performed and frequency:

BODY WEIGHT: Yes
- Time schedule for examinations: Weekly

Sacrifice and pathology:

GROSS PATHOLOGY: Yes

Results and discussion

Results of examinations

Clinical signs:

not examined

Mortality:

mortality observed, treatment-related

Description (incidence):

- A total of 4 deaths occurred and two of these occurred in the control group

Body weight and weight changes:

no effects observed

Food consumption and compound intake (if feeding study):

not examined

Food efficiency:

not examined

Water consumption and compound intake (if drinking water study):

not examined

Ophthalmological findings:

not examined

Haematological findings:

not examined

Clinical biochemistry findings:

not examined

Urinalysis findings:

not examined

Behaviour (functional findings):

not examined

Immunological findings:

not examined

Organ weight findings including organ / body weight ratios:

no effects observed

Gross pathological findings:

no effects observed

Neuropathological findings:

not examined

Histopathological findings: non-neoplastic:

no effects observed

Description (incidence and severity):

Histopathological examination of sections of the liver, kidney, or spleen revealed no tissue changes that could be attributed to the ingestion of potassium niobate

Histopathological findings: neoplastic:

not examined

Other effects:

not examined

Effect levels

Key result

Dose descriptor:

NOAEL

Effect level:

10 mg/kg diet

Based on:

test mat.

Sex:

male

Applicant's summary and conclusion

Conclusions:

Potassium niobate was fed to three groups of 5 weaned, male rats each at dietary levels of 0, 0.10 and 1 % for a duration of 7 weeks. No treatment related effects were observed.

Executive summary:

Potassium niobate was fed to three groups of 5 weaned, male rats each at dietary levels of 0, 0.10 and 1 % for a duration of 7 weeks. Histopathological examination of sections of the liver, kidney, or spleen revealed no tissue changes that could be attributed to the ingestion of potassium niobate.