Registration Dossier
Registration Dossier
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EC number: 291-130-9 | CAS number: 90341-97-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-{[3-({[2-hydroxy-3-(2-methylphenoxy)propyl]amino}methyl)-3,5,5-trimethylcyclohexyl]amino}-3-(2-methylphenoxy)propan-2-ol
- Molecular formula:
- C29H42O4
- IUPAC Name:
- 1-{[3-({[2-hydroxy-3-(2-methylphenoxy)propyl]amino}methyl)-3,5,5-trimethylcyclohexyl]amino}-3-(2-methylphenoxy)propan-2-ol
- Reference substance name:
- 1-{[3-(aminomethyl)-3,5,5-trimethylcyclohexyl]amino}-3-(2-methylphenoxy)propan-2-ol
- Molecular formula:
- C19H29O2
- IUPAC Name:
- 1-{[3-(aminomethyl)-3,5,5-trimethylcyclohexyl]amino}-3-(2-methylphenoxy)propan-2-ol
- Reference substance name:
- 3-aminomethyl-3,5,5-trimethylcyclohexylamine
- EC Number:
- 220-666-8
- EC Name:
- 3-aminomethyl-3,5,5-trimethylcyclohexylamine
- Cas Number:
- 2855-13-2
- Molecular formula:
- C10H22N2
- IUPAC Name:
- 3-Aminomethyl-3,5,5-trimethylcyclohexanamine
- Reference substance name:
- 1-{[2-hydroxy-3-(2-methylphenoxy)propyl][3-({[2-hydroxy-3-(2-methylphenoxy)propyl]amino}methyl)-3,5,5-trimethylcyclohexyl]amino}-3-(2-methylphenoxy)propan-2-ol
- Molecular formula:
- C39H55N2O6
- IUPAC Name:
- 1-{[2-hydroxy-3-(2-methylphenoxy)propyl][3-({[2-hydroxy-3-(2-methylphenoxy)propyl]amino}methyl)-3,5,5-trimethylcyclohexyl]amino}-3-(2-methylphenoxy)propan-2-ol
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Constituent 3
Constituent 4
In vitro test system
- Test system:
- artificial membrane barrier model
- Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- 500 mg
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- 1
- Value:
- 57.68
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- 2
- Value:
- 56.9
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- 3
- Value:
- 57.1
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- 4
- Value:
- 56.83
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- Corrosivity of the Isophoronediamine-cresyl glycidyl ether adduct was tested using Corrositex, artificial barrier penetration method. Based on results of the study, test material is classified in corrosivity category 1C.
- Executive summary:
Corrosivity of the Isophoronediamine-cresyl glycidyl ether adduct was tested using Corrositex, artificial barrier penetration method. Based on results of the study, test material is classified in corrosivity category 1C.
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