Registration Dossier
Registration Dossier
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EC number: 823-458-0 | CAS number: 1631149-46-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 6,6'-(1-phenylethane-1,2-diyl)bis(6H-dibenzo[c,e][1,2]oxaphosphinine) 6,6'-dioxide
- EC Number:
- 823-458-0
- Cas Number:
- 1631149-46-6
- Molecular formula:
- C32H24O4P2
- IUPAC Name:
- 6,6'-(1-phenylethane-1,2-diyl)bis(6H-dibenzo[c,e][1,2]oxaphosphinine) 6,6'-dioxide
- Test material form:
- solid: particulate/powder
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Cell type:
- other: RECONSTRUCTED HUMAN EPIDERMIS 0.5 cm2 reconstructed epidermal of normal human keratinocytes
- Cell source:
- other: The inserts (SkinEthicTM RHE or RHE) supplied by SkinEthic.
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
Test animals
- Species:
- other: reconstructed human epidermis
Test system
- Type of coverage:
- not specified
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- ca. 75.12
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- According to OECD 439:2015, under the test conditions applied, the test substance is considered NON IRRITAN.
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