Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: oral, other
Remarks:
QSAR prediction
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: (Q)SAR Prediction
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
QSAR
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(5´R,8´S,10´R,13´S,14´S)-13´-methyl-1´,2´,6´,7´8´,12´,13´,14´,15´,16´-decahydro-17´H-spiro[1,3-dioxolane-2,3´-[5,10]epoxycyclopenta[a]phenantren]-17´-one
EC Number:
821-898-8
Cas Number:
39931-87-8
Molecular formula:
C20H26O4
IUPAC Name:
(5´R,8´S,10´R,13´S,14´S)-13´-methyl-1´,2´,6´,7´8´,12´,13´,14´,15´,16´-decahydro-17´H-spiro[1,3-dioxolane-2,3´-[5,10]epoxycyclopenta[a]phenantren]-17´-one
Test material form:
solid: particulate/powder

Test animals

Species:
rat

Results and discussion

Effect levels

Key result
Dose descriptor:
NOEL
Effect level:
62.1 mg/kg bw/day (nominal)
Remarks on result:
not measured/tested
Remarks:
Predicted value

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion