Registration Dossier
Registration Dossier
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EC number: 213-361-6 | CAS number: 939-48-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental studies were performed in a reliable research institute prior to establishment of international guidelines and GLP
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding toxicity Data: List IV
- Author:
- Smyth, Jr. H.F.
- Year:
- 1 951
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med. 4: 119-122
- Reference Type:
- review article or handbook
- Title:
- Safety assessment of alkyl benzoates as used in cosmetics
- Author:
- Becker LC, Bergfeld WF, Belsito DV, et al.
- Year:
- 2 012
- Bibliographic source:
- Int. J. Toxicol. 31:342S-72S
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day
- GLP compliance:
- no
- Remarks:
- Precedes establishment of GLP
- Test type:
- standard acute method
Test material
- Reference substance name:
- Isopropyl benzoate
- EC Number:
- 213-361-6
- EC Name:
- Isopropyl benzoate
- Cas Number:
- 939-48-0
- Molecular formula:
- C10H12O2
- IUPAC Name:
- propan-2-yl benzoate
- Test material form:
- other: liquid
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- saturated vapour
- Details on study design:
- Minimal data is available on this 1951 study. The maximum concentration was described qualitatively as "saturated vapour" and the amount of time elapsed before death was observed in any animal was reported. The type of exposure is most likely whole body, but is not specifically described. After exposure, animals were observed and mortality assessed for 14 days.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- other: described qualitatively as "saturated vapour"
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No deaths occurred in rats after 4 h of inhalation exposure to saturated vapour
Applicant's summary and conclusion
- Conclusions:
- No deaths occurred in rats after 4 h of inhalation exposure to saturated vapour of isopropyl benzoate
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