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Endpoint:
explosive properties of explosives
Type of information:
other: Expert statement
Adequacy of study:
supporting study
Study period:
2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Expert statement following no specific guideline and without detailed description of results.
Qualifier:
no guideline followed
Version / remarks:
Expert statement
Principles of method if other than guideline:
Expert statement.
GLP compliance:
no
Specific details on test material used for the study:
- Batch n°: M14IB5308
- Analytical purity: 99.6%
- Expiration date: 03 February 2016
- Storage condition: at room temperature

None of the components of the test item does contain chemical groups which are associated with explosive properties. The molecular structures of impurities present at =< 1% were not taken into account.

In conclusion, JNJ-16479489 -AAA (T001159) has no explosive properties.

Interpretation of results:
GHS criteria not met
Remarks:
Non explosive
Conclusions:
It is concluded that the substance T001159 does not have explosive properties.
Endpoint:
explosive properties of explosives
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The test is performed according to EC guideline with some small deviations. However, there is no information on purity of the substance.
Qualifier:
according to
Guideline:
EU Method A.14 (Explosive properties)
Deviations:
yes
Remarks:
1)The weight of the falling hammer is 5 kg and dropped from 0.8 m, however, the energy applied is the same as guideline, 40 J or 40 Nm. 2) In contrast to the EC guideline aluminium foil is used to pack the substance. 3) Ten tests are performed.
GLP compliance:
not specified
Parameter:
other: More sensitive to shock than m-dinitrobenzene
Remarks:
migrated information
Remarks on result:
negative (not further specified)
Remarks:
If all tests according to Lütolf method are negative, powder can be considered not shock sensitive as reference substance meta-dinitrobenzene is not shock sensitive in similar conditions (although not tested simultaneously in this study)

RESULTS:

-10 times negative, not shock sensitive (sensitivity > 39.2 Nm)

Interpretation of results:
GHS criteria not met
Conclusions:
The test substance is not shock sensitive (sensitivity > 39.2 Nm).

Description of key information

Based on an expert statement (Reingruber, 2016), T001159 does not contain any chemical groups indicating explosive properties. Further testing was not required and T001159 is considered not to have explosive properties.

Key value for chemical safety assessment

Explosiveness:
non explosive

Additional information

A study of which the reliability was not assignable (K4) carried out by the Janssen Pharmaceutica Process Safety Center concluded that the test substance is not shock sensitive (sensitivity > 39.2 Nm) (Lütolf method). This study supports the conclusions of the expert statement.

Justification for classification or non-classification

T001159 does not need to be classified as explosive as based on its chemical structure T001159 does not contain any chemically instable or highly energetic groups that might lead to an explosion.