Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-535-7 | CAS number: 84929-51-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Thymus vulgaris, Labiatae.
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 4.658 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- EC50 of green algae is 4.658 mg/L for carvacrol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.592 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- EC50 of green algae is 0.592 mg/L for gamma-terpinene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 5.929 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- EC50 of green algae is 5.929 mg/L for linalol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 1.936 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 of green algae is 1.936 mg/L for p-cymene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 4.658 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 of green algae is 1.087 mg/L for thymol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.075 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 of green algae is 0.075 mg/L for beta-caryophyllene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13.795 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 of green algae is 13.795 mg/L for borneol.
Referenceopen allclose all
Description of key information
Based on a weight of evidence approach, the toxicity of assessed substance to algae during 96 hours can be estimated using adequate toxicity data of the major constituents, greater than 1% in the mixture.
Seven major constituents were considered, representing about 80% of the mixture.
The toxicity to green algae were estimated using the following additivity formula, as recommended in the Regulation (EC) No 1272/2008 (CLP) section 4.1.3.5.2:
∑ Ci / L(E)C50m = ∑ (Ci / L(E)C50i)
Where,Ci = concentration of component i (weight percentage);
L(E)C50i = LC50 or EC50 for component i, in mg/L; L(E)C50m = L(E)C50 of the part of the mixture with test data.
Based on data presented below, the EC50 value 96 hours for UVCB substance is calculated at 1.15 mg/L for green algae.
These data are summarized in the table below :
| Main constituent | CAS Number | EC50 Green algae 96h (mg/L) | Source |
| Thymol (at 39.2%) | 89-93-8 | 4.658 | ECOSAR v1.11 |
| P-cymene (at 18%) | 99-87-6 | 1.936 | ECOSAR v1.11 |
| Gamma-terpinene (at 11%) | 99-85-4 | 0.592 | ECOSAR v1.11 |
| Linalol (at 4.55%) | 78-70-6 | 5.929 | ECOSAR v1.11 |
| Carvacrol (at 2.25%) | 499-75-2 | 4.658 | ECOSAR v1.11 |
| Beta-carypohyllene (at 2.4%) | 87-44-5 | 0.075 | ECOSAR v1.11 |
| Borneol (at 2.7%) | 507-70-0 | 13.795 | ECOSAR v1.11 |
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1.15 mg/L
Additional information
With a EC50 algae value 1.15 mg/l and some constituents (thymol with log Kow <4), the substance is not classified according to the table 4.1.0 of CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
