Registration Dossier
Registration Dossier
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EC number: 208-577-2 | CAS number: 533-75-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 to 24 February 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildesheim, Germany
- Type of method:
- flask method
- Key result
- Water solubility:
- 35.3 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 4.1
- Conclusions:
- A water solubility value of 35.3 g/L (at 20 °C, pH = 4.1) was determined for the test substance according to OECD 105.
Reference
The following table reports the results of the water solubility test.
Preincubation time |
Replicate No. |
Concentration [g/L] * |
Mean [g/L] |
24 h |
1 |
35.1 |
35.5 |
2 |
35.9 |
||
48 h |
1 |
34.7 |
35.1 |
2 |
35.4 |
||
72 h |
1 |
35.9 |
35.2 |
2 |
34.4 |
||
Mean (24 - 72 h) |
35.3 |
||
Deviation [%] (24 - 72 h) |
1.3 |
||
* Mean value of two injections, dilution factor of 333.3 and exact weight of the standard taken into account
The temperature during the pre-incubation and the thermostatisation phase resulted to be 30.06 ± 0.09 °C and 20.00 ± 0.05 °C, respectively.
A mean pH-value of 4.1 was determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.
The test samples showed no Tyndall-Effect.
Conclusions
The solubility of the test item was determined at 20 ± 0.5 °C to be 35.3 g/L (pH 4.1).
Description of key information
Water solubility: 35.2 g/L at 20 °C, pH 4.1 (EU Method A.6., flask method)
Key value for chemical safety assessment
- Water solubility:
- 35.2 g/L
- at the temperature of:
- 20 °C
Additional information
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