Sodium bromate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not specified

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Toxicological Study of Potassium Bromate. I. Absorption, Metabolism and Excretion of Potassium Bromate after oral Administration in Rats

Author:

Kawana, K.; Nakaoka, T.; Horiguchi, Y.; Watanabe, S.; Watanabe, S.; Kawauchi, S.

Year:

1991

Bibliographic source:

Eisei Kaguku 1991, 37, (4), 258-265.

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

not specified

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium bromate

EC Number:

231-829-8

EC Name:

Potassium bromate

Cas Number:

7758-01-2

Molecular formula:

BrHO3.K

IUPAC Name:

potassium bromate

Test material form:

solid: crystalline

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: unspecified

Doses:

85, 159, 177, 325, 337, 602 mg/kg body weight

No. of animals per sex per dose:

85 mg/kg: 5 m
159 mg/kg: 5 m
177 mg/kg: 5 f
325 mg/kg: 5 m
337 mg/kg: 5 f
602 mg/kg: 5 m

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

157 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

Category 2 based on GHS criteria

Conclusions:

Under the experimental conditions, the substance had a LD50 by oral administration of 157 mg/kg bw in male and female rats.