Registration Dossier
Registration Dossier
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EC number: 615-244-9 | CAS number: 71035-05-7
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- peer rewied
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenicity tests of diethylene glycol
- Author:
- Yoshida S, Fujita H, Sasaki M
- Year:
- 1 986
- Bibliographic source:
- Ann Rep Tokyo Metrop Res Lab Publ Health 37 : 442 – 446
Materials and methods
- GLP compliance:
- not specified
- Type of assay:
- other: cromosomal aberration
Test material
- Reference substance name:
- 2-(2-hydroxyethoxy)ethan-1-ol
- Cas Number:
- 111-46-6
- Molecular formula:
- C4H10O3
- IUPAC Name:
- 2-(2-hydroxyethoxy)ethan-1-ol
Constituent 1
Test animals
- Species:
- hamster
- Strain:
- not specified
Administration / exposure
- Route of administration:
- other: intraperitoneal or oral gavage
- Vehicle:
- water if gavaged
- Duration of treatment / exposure:
- 3 weeks
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Remarks:
- intraperitoneal
- Dose / conc.:
- 2 other: % w/w drinking water
- Remarks:
- oral gavage
- Control animals:
- not specified
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- a slight increase in chromosomal aberrations in the form of gaps was described but an increase in the incidence of gaps, however, is not evidence of chromosomal damage.
Applicant's summary and conclusion
- Conclusions:
- Negative for chromosomal damage
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