Registration Dossier
Registration Dossier
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EC number: 947-361-9 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to REACH Annex XI, the conduct of an acute inhalation toxicity study is scientifically unjustified. The test substance has a low vapor pressure, so the potential for the unintended generation of inhalable forms such as dust or aerosols is low. The most likely route of human exposure for workers and consumers is the dermal route. However,small quantities of the TEA-Esterquats are manufactured into spray (product) applications for professional and consumer uses. For spray applications, the concentration of diluted preparations for use is ≤ 0,5% active ingredient (worst case). Results of laboratory animal studies show a very low acute toxicity after oral or dermal exposure. Therefore the acute intrinsic toxic activity of the TEA-Esterquats is considered to be very low. The occurrence of a systemic toxicity relevant to humans after inhalation is unlikely and therefore the conduct of an acute inhalation toxicity study is unjustified.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
