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EC number: 221-312-5
CAS number: 3064-73-1
In a reverse gene mutation assay in bacteria (17_053-007M), strains of
S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2 uvr A
were exposed to TiBTD (97%) in DMF at concentrations of 5000, 1581, 500,
158.1, 50, 15.81, 5 and 1.58 μg/plate (direct plate incorporation;
experiment 1) and 5000, 1581, 500, 158.1, 50, 15.81 and 5 μg/plate (20
minute pre-incubation; experiment 2) in the presence and absence of
mammalian metabolic activation (Phenobarbital/β- naphthoflavone-induced
rat liver S9).
TiBTD was tested up to the limit concentration (5000 µg/plate). The
positive controls induced the appropriate responses in the corresponding
strains. There was no evidence of induced mutant colonies over
This study is classified as acceptable. This study satisfies the
requirement for Test Guideline OECD 471 for in vitro mutagenicity
(bacterial reverse gene mutation) data.
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