Registration Dossier
Registration Dossier
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EC number: 814-114-0 | CAS number: 848318-58-1
Endpoint summary
Administrative data
Description of key information
Invertebrates: Under the conditions of the test, Sedolisin, batch PPF38268 was found not to be toxic to Daphnia magna at a nominal concentration up to 119.2 mg enzyme concentrate dry matter/L (equivalent to 24.7 mg active enzyme protein/L) after 48h exposure. Thus, no 48h EC50 could be calculated and must be > 119.2 mg enzyme concentrate dry matter/L (> 24.7 mg active enzyme protein/L).
Subtilisin, batch PPA 4046 was used as a read-across and the 48-hour EC50 of the test substance for the immobilisation of Daphnia magna was nominal 60.4 mg enzyme concentrate dry matter/L corresponding to 12.4 mg active enzyme protein/L.
Algae: Under the conditions of the test, Sedolisin, batch PPF38268 was found not to be toxic to Daphnia magna at a nominal concentration up to 119.2 mg enzyme concentrate dry matter/L (24.7 mg aep/L) after 48h exposure. Thus, no 48h EC50 could be calculated and must be > 119.2 mg enzyme concentrate dry matter/L (equivalent to > 24.7 mg active enzyme protein/L).
Subtilisin was used as read-across: The EC50 was 9.8 mg enzyme concentrate dry matter/L (corresponding to 5.02 mg active enzyme protein/L). NOEC for the growth rate was 0.042 mg enzyme concentrate dry matter/L.
Additional information
The Subtilisin EC50 will be used as worst-case scenario.
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