N,N'-methylenebis[methacrylamide]

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2015-07-22

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Justification for type of information:

1. SOFTWARE
OECD QSAR Toolbox v 3.3

2. MODEL (incl. version number)
Trend Analysis

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS 2359-15-1
SMILES CC(=C)C(=O)NCNC(=O)C(C)=C

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
please refer to the attached justification under 'Attached justification'

5. APPLICABILITY DOMAIN
please refer to the attached justification under 'Attached justification'

6. ADEQUACY OF THE RESULT
please refer to the attached justification under 'Attached justification'

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2015

Report date:

2015

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

- Software tool(s) used including version: OECD QSAR Toolbox
- Model(s) used: Trend Analysis
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N,N'-methylenebis[methacrylamide]

EC Number:

219-102-3

EC Name:

N,N'-methylenebis[methacrylamide]

Cas Number:

2359-15-1

Molecular formula:

C9H14N2O2

IUPAC Name:

N,N'-methylenebis(2-methylacrylamide)

Sampling and analysis

Analytical monitoring:

no

Results and discussion

Effect concentrations

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

313 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: QSAR estimation

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Conclusions:

Based on the prediction performed by Trend Ánalysis with the OECD QSAR Toolbox the EC50 value for aquatic algae is 313 mg/L.

Executive summary:

The 72h EC50 value for toxicity to aquatic algae and cyanobacteria was estimated by Trend Analysis performed with the OECD QSAR Toolbox. The estimation is based on a linear approximation conducted with 4 substances which share the same structural fragments and therefore are considered to exhibit similar ecotoxicological behaviour. For all substances in this comparison group experimental EC50 values are available. Based on the prediction the EC50 value for aquatic algae is 313 mg/L.