N,N'-methylenebis[methacrylamide]

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006-11-01 to 2006-12-19

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Report date:

2008

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - HPLC Method)

Version / remarks:

Directive 92/69/EEC, Official Journal L 383 A

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

N,N'-methylenebis[methacrylamide]

EC Number:

219-102-3

EC Name:

N,N'-methylenebis[methacrylamide]

Cas Number:

2359-15-1

Molecular formula:

C9H14N2O2

IUPAC Name:

N,N'-methylenebis(2-methylacrylamide)

Test material form:

solid

Details on test material:

Crystalline, odourless, colourless

Study design

Analytical method:

high-performance liquid chromatography

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Partition coefficient:

ca. 1

Remarks on result:

other: No information on pH value is given. Temperature is described as ambient.

Details on results:

A summary of the results of the HPLC measurements of the reference compounds and the test item is given in section “any other information on results incl. tables”.

Any other information on results incl. tables

Sample No.	tR1(min)	tR2(min)	tR(min)	k´	Log k´(x)	Log Pow (y)
Urea (inert marker)	0.86	0.86	0.86
Benzylalcohol	2.96	2.96	2.96	2.442	0.338	1.1
Benzonitrile	5.33	5.33	5.33	5.198	0.716	1.6
Phenylacetonitrile	5.45	5.47	5.46	5.349	0.728	1.6
Acetophenone	6.61	6.61	6.61	6.686	0.825	1.7
Methylbenzoate	14.81	14.82	14.815	16.227	1.21	2.1
Ethylbenzoate	33.44	33.51	33.475	37.924	1.579	2.6
Test item	2.43			1.826	0.262	1
Test item		2.43		1.826	0.262	1
Mean value						1

The log Pow values of the test item fall within a range of ± 0.005 units, thus the test is satisfactory.

Applicant's summary and conclusion

Conclusions:

The partition coefficient n-octanol / water (log Pow) of the test item is 1.00.

Executive summary:

The partition coefficient n-octanol / water of N,N'-Methylene-bis[methacrylamide] was determined according to OECD guideline No. 117 and EU test method A.8 (Directive 92/69/EEC, Official journal L 383 A) with the HPLC method. The partition coefficient n-octanol / water (log P_ow) was determined to be 1.00 at ambient temperature.