Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: prediction
Title:
QSAR prediction of levonorgestrel acetate
Author:
Gedeon Richter Plc.
Year:
2016
Bibliographic source:
QSAR Toolbox

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
(1R,3aS,3bR,9aR,9bS,11aS)-11a-ethyl-1-ethynyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
EC Number:
604-013-8
Cas Number:
13732-69-9
Molecular formula:
C23H30O3
IUPAC Name:
(1R,3aS,3bR,9aR,9bS,11aS)-11a-ethyl-1-ethynyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 1535
Metabolic activation:
with and without
Species / strain:
S. typhimurium TA 1537
Metabolic activation:
with and without
Species / strain:
S. typhimurium TA 97
Metabolic activation:
with and without
Species / strain:
S. typhimurium TA 100
Metabolic activation:
with and without
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion