3,7-bis(diethylamino)phenoxazin-5-ium tetrachlorozincate (2:1)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary source

Data source

Reference

Reference Type:

secondary source

Title:

INITIAL SUBMISSION:TOXICITY STUDY

Author:

National Technical Reports Library

Year:

1992

Bibliographic source:

INITIAL SUBMISSION

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as metioned below

Principles of method if other than guideline:

Acute oral toxicity of Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) in rats.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methyltriphenylphosphonium bromide

EC Number:

217-218-9

EC Name:

Methyltriphenylphosphonium bromide

Cas Number:

1779-49-3

Molecular formula:

C19H18P.Br

IUPAC Name:

Methyltriphenylphosphonium bromide

Details on test material:

Name - Methyltriphenylphosphonium bromide
InChI: 1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
Smiles:[P+](c1ccccc1)(c1ccccc1)(c1ccccc1)C.[BrH-]
- Molecular formula (if other than submission substance):C19H18BrP
- Molecular weight (if other than submission substance):357.229 g/mole
- Substance type:Organic

Specific details on test material used for the study:

Name - Methyltriphenylphosphonium bromide
InChI: 1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
Smiles:[P+](c1ccccc1)(c1ccccc1)(c1ccccc1)C.[BrH-]
- Molecular formula (if other than submission substance):C19H18BrP
- Molecular weight (if other than submission substance):357.229 g/mole
- Substance type:Organic

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 10%

Doses:

Range of 50-800 mg/kg

No. of animals per sex per dose:

Total = 20

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: Animals were observed for mortality, clinical signs and body weight change.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

approximate LD50

Effect level:

118 mg/kg bw

Based on:

test mat.

95% CL:

84 - 167

Remarks on result:

other: 50% mortality was observed

Mortality:

50% mortality was observed at 118 mg/kg bw

Clinical signs:

other: Clinical signs were observed in treated rats. At 50 mg/kg symptoms like diarrhea was observed in 2-4 hr. which was normal within 24 hr. At 100 mg/kg symptoms like diarrhea was observed in 2-4 hr. At the range of 200-800 mg/kg: Tremors, convulsions, diar

Gross pathology:

not specified

Other findings:

not specified

Any other information on results incl. tables

Table: Acute oral toxicity of Methyltriphenylphosphonium Bromide

Solution	Animals* No. and Species	Route**	Dose Range mg/kg	Approx. LD50*** mg/kg	Symptoms	Time of death	Weight change 2 wks
Acute Toxicity 10% in H2O	20R	PO	50-800	118 84-167	50 mg/kg: Sl. to mod. w., some diarrhea 2-4 hr., normal 24 hr. 100 mg/kg: Mod. to severe wk., diarrhea 2-4 hr. 200-800 mg/kg: Tremors, convulsions, diarrhea and death <24 hr.	2.5-24 hr	7+

 

*R= Rat

**PO= Orally

***NRC= No range calculable

Remarks: Moderately toxic to rats orally and highly toxic to mice orally.

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

The LD50 was considered to be approximately 118 mg/kg with confidential limit of 84-167mg/kg bw, when rats were treated with Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) via oral route.

Executive summary:

The acute oral toxicity of Methyltriphenylphosphonium bromide (CAS no: 1779-49-3) was tested in 20 rats at the dose concentration range of 50-800 mg/kg bw. The test substance was dissolved as 10% in water (Vehicle). Animals were observed for mortality, clinical signs and body weight change for 14 days. 50% mortality was observed within 2.5-24 hr at 118 mg/kg bw. Clinical signs were observed in treated rats. At 50 mg/kg symptoms like diarrhea was observed in 2-4 hr. which was normal within 24 hr, considered to be slightly to moderate; At 100 mg/kg symptoms like diarrhea was observed in 2-4 hr which was considered as moderate to severe; and At the range of 200-800 mg/kg: Tremors, convulsions, diarrhea and death within 24 hr was observed which was considered to be highly toxic. Weight change was observed in more than 7 rats. Therefore, LD50 was considered to be approximately 118 mg/kg with confidential limit of 84-167mg/kg bw, when rats were treated with Methyltriphenylphosphonium bromide via oral route.