Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorothioxanthen-9-one
EC Number:
201-667-2
EC Name:
2-chlorothioxanthen-9-one
Cas Number:
86-39-5
Molecular formula:
C13H7ClOS
IUPAC Name:
2-chlorothioxanthen-9-one

Results and discussion

In vitro

Results
Irritation parameter:
other: ICE class
Value:
ca. 1
Remarks on result:
other:
Remarks:
ICE class is I for all values of the test item.
Other effects / acceptance of results:
In both experiments, no significant corneal swelling, corneal opacity change or fluorescein retention change was observed during the observation period.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Based on the in vitro eye irritaion tests in isolated chicken eyes, the test item is not irritant to eye.