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Diss Factsheets

Physical & Chemical properties

Density

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Reference
Endpoint:
density, other
Remarks:
density
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
GLP compliance:
no
Type of method:
pycnometer method
Key result
Type:
pour density
Density:
0.421 g/cm³
Temp.:
29.1 °C
Remarks on result:
other: Pressure at 968.6 hPa
Remarks:
No other data available
Key result
Type:
tap density
Density:
0.541 g/cm³
Temp.:
29.1 °C
Remarks on result:
other: Pressure at 968.6 hPa
Remarks:
No other data available

Observation Table :

S. No.

Method Details

Observed Values

1stObservation

  2ndObservation

1.                   

Guideline

OECD 109

 

 

2.                   

Method

IS 4730 : 1994 (Reaffirmed 2010) – Method for Determination of Density of Liquids (First Revision)

3.                   

Principle of Method

Determination of the mass at a given temperature of a volume of the material contained in a density bottle (pyknometer) and determination of the volume of the latter by determining the mass of the corresponding volume of water at the same temperature. The density is obtained by dividing the mass of material by its volume.

 

 

4.                   

Test temperature    

(°C)

20oC

20oC

5.                   

Atmospheric pressure

(hPa)

970.2 hPa

970.4 hPa

6.                   

Weight of empty dry pyknometer(X)

g

 29.962 g

 31.115 g

7.                   

Weight of pyknometer + test item(Y)

g

 85.322 g

 85.275 g

8.                   

Apparent mass of test item(M1)

(M1= Y - X)g

 55.36 g

 54.16 g

9.                   

Weight of pyknometer + water(Z)

g

 80.325 g

 80.323 g

10.               

Apparent mass of water(M2)

(M2 = Z - X)g

 50.363 g

 49.208 g

11.               

Buoyancy correction(A)

A=(*ρat× M2)

 0.0588

 0.0574

12.               

Density of water** at test temperature

                g/cm3(ρtw)

0.9982 g/cm3

0.9982 g/cm3
Conclusions:
The mean pour density and tapped density of the test chemical was observed to be 0.4211 g/cm³ and 0.5410 g/cm³ at 29.1°C and 968.6 hPa.
Executive summary:

The density of Test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test item was observed to be 0.4211 g/cm³ and 0.5410 g/cm³ at 29.1°C and 968.6 hPa.

Description of key information

The mean pour density and tapped density of the test chemical was observed to be 0.4211 g/cm³ and 0.5410 g/cm³ at 29.1°C and 968.6 hPa.

Key value for chemical safety assessment

Additional information

The density of Test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test chemical was observed to be 0.4211 g/cm³ and 0.5410 g/cm³ at 29.1°C and 968.6 hPa.