Registration Dossier
Registration Dossier
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EC number: 271-928-3 | CAS number: 68630-95-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs.
- EC Number:
- 263-171-2
- EC Name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs.
- Cas Number:
- 61791-39-7
- Molecular formula:
- UVCB. Not applicable (a generic molecular formula cannot be provided for this specific UVCB substance).Average Empirical Formula: C H N O 22 40-44
- IUPAC Name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Alkyl imidazoline is a UVCB material contininag structures which are very similar to the substance under test.
There are no studies for this substance and due to a ban on animal testing for such end points, it is necessry to try to find an alternative way of making an assessment using other substances that have been tested in-vivo in previous years.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 213 - <= 2 546 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 259 - <= 2 638 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 1 515 - <= 2 349 mg/kg bw
Any other information on results incl. tables
Alkyl imidazoline, 1-(2-Hydroxyethyl)-2-alkyl*-2-imidazoline (*as in fatty acids of tall oil), has been tested in the following acute toxicity
tests. With Sprague-Dawley rats (MRID No. 42293001), alkyl imidazoline demonstrated an acute oral LD of 1948 (1259-2638) mg/kg body weight 50 for male rats, 1880 (1213-2546) mg/kg for female rats, and 1932 (1515 - 2349) mg/kg for combined sexes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Alkyl imidazoline is a UVCB material contininag structures which are very similar to the substance under test.
There are no studies for this substance and due to a ban on animal testing for such end points, it is necessry to try to find an alternative way of making an assessment using other substances that have been tested in-vivo in previous years.
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