Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: rat, Wistar SPF-breeded, strain: Hsd Win:WU

Administration / exposure

Vehicle:
other: solved in polyethylene glycol, application by fixed gavage

Results and discussion

Effect levels
Sex:
male/female
Mortality:
Male: 200 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 633 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 200 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 633 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
Signs of toxicity related to dose levels:
staggered gait and apathy after the 200 and 633 mg/kg dose;

paralysis of the extemities after the 2000 mg/kg dose.
Gross pathology:
Effects on organs:
There was a accumulation of a yellowish liquid in the
stomach of the died animals at 2000 mg/ka dose.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU