Registration Dossier
Registration Dossier
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EC number: 200-115-8 | CAS number: 51-67-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from hand book
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Absorption, Distribution and Metabolism of 4-(2-aminoethyl)phenol
- Author:
- S.D. Gangolli
- Year:
- 1 999
- Bibliographic source:
- Dictionary of Substances and their Effects (DOSE), 2nd edition, Volume 7-part 5, 1999
Materials and methods
- Objective of study:
- absorption
- distribution
- metabolism
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- In vivo Absorption, Distribution and Metabolism study of 4-(2-aminoethyl)phenol in human
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-(2-aminoethyl)phenol
- EC Number:
- 200-115-8
- EC Name:
- 4-(2-aminoethyl)phenol
- Cas Number:
- 51-67-2
- Molecular formula:
- C8H11NO
- IUPAC Name:
- 4-(2-aminoethyl)phenol
- Details on test material:
- Name: 4-(2-Aminoethyl)phenol
SMILES:NCCc1ccc(O)cc1
InChI:1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
Mol. formula: C8H11NO
Molecular Weight: 137.1809 g/mole
Constituent 1
- Specific details on test material used for the study:
- Name: 4-(2-Aminoethyl)phenol
SMILES:NCCc1ccc(O)cc1
InChI:1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
Mol. formula: C8H11NO
Molecular Weight: 137.1809 g/mole - Radiolabelling:
- not specified
Test animals
- Species:
- other: Human
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- not specified
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- not specified
Doses / concentrations
- Remarks:
- no specified
- No. of animals per sex per dose / concentration:
- not specified
- Control animals:
- not specified
- Positive control reference chemical:
- not specified
- Details on study design:
- not specified
- Details on dosing and sampling:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary studies:
- not specified
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- 4-(2-aminoethyl) phenol can be absorbed from the gastro-intestinal tract
- Type:
- distribution
- Results:
- 4-(2-aminoethyl) phenol can penetrate most organs, including the brain. It can be deaminated by monoamine oxidase types A and B in a variety of tissues, including the wall of the gastro-intestinal tract and the central nervous system
- Type:
- metabolism
- Results:
- 4-(2-aminoethyl) phenol can be conjugated, and production of tyramine-0-sulfate as a urinary metabolite
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- 4-(2-aminoethyl) phenol can be absorbed from the gastro-intestinal tract
Metabolite characterisation studies
- Metabolites identified:
- yes
- Remarks:
- tyramine-0-sulfate
Applicant's summary and conclusion
- Conclusions:
- 4-(2-aminoethyl)phenol is likely to exhibit low bio-accumulation potential based on study results and use.
- Executive summary:
Available data pertaining to the in-vivoAbsorption, Distribution and Metabolism of the chemical 4-(2-aminoethyl)phenol suggests absorbed from the gastro-intestinal tract and distributed by penetrate in most organs, including the brain. It can be deaminated by monoamine oxidase types A and B in a variety of tissues, including the wall of the gastro-intestinal tract and the central nervous system.Metabolism of 4-(2-aminoethyl) phenolby conjugation, and production of tyramine-0-sulfate as a urinary metabolite.Thus, there is no evidence that they or their metabolites would accumulate in tissues and cause a concern for consumer safety. Also, the Use Therapeutically as the hydrochloride as a sympathomimetic agent. Hence it is concluded that 4-(2-aminoethyl)phenolis likely to exhibit low bio-accumulation potential based on study results and use.
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