Disodium 7-[[2-(acetylamino)-4-[(5-chloro-2,6-difluoro-4-pyrimidinyl)amino]phenyl]azo]naphthalene-1,3-disulphonate

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 01st, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

adopted July 27, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

31 May 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

March 1998

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: OECD giudeline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

adopted May 12, 1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

The test item was used in its initial form.

Decomposition:

yes

Decomp. temp.:

264 - 387 °C

Before the test the appearance of the test item was orange powder; after the experiments, the test item became black powder.

During the heating exothermic signals were observed in the temperature range of approx. 264 – 387 °C that can be associated with the decomposition of the test item.

	Experiment 1	Experiment 2	Mean
Left Limit [°C]	266.24	262.67	264.46
Right Limit [°C]	392.13	382.11	387.12
Onset of effect [°C]	358.81	350.00	354.405
Energy [J/g]	268.28	291.11	279.7

	Sample weight [mg]	Loss of Mass of the Sample (%)	Onset of effect [°C]	Endset of effect [°C]	Left Limit [°C]	Right Limit [°C]	Energy [J/g]
Experiment 1	2.67	33.7	358.81	374.17	266.24	392.13	-268.28 (exothermic)
Experiment 2	2.18	31.7	350.00	382.11	262.67	382.11	-291.11 (exothermic)

Conclusions:

The substance decomposes before melt/boil, at ca 264 -387 °C.

Executive summary:

The thermal behaviour of the substance was investigated using Differential Scanning Calorimtry method, according to the OECD guideline 102 and 113. The test was carried out at normal atmospheric pressure. The experiment was performed in duplicate.

Before the test the appearance of the test item was orange powder; after the experiments, the test item became black powder. Using a linear heating rate of 10 °C/min the melting point was not observed from room temperature up to 500 °C. During the heating exothermic signals were observed in the temperature range of approx. 264 – 387 °C that can be associated with the decomposition of the test item.

Conclusion

The substance decomposes before melt/boil, at ca 264 -387 °C.

Description of key information

The substance decomposes before melt/boil, at ca 264 -387 °C.

Additional information

OECD 102/113 - Differential Scanning Calorimetry analysis