Registration Dossier
Registration Dossier
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EC number: 408-090-7 | CAS number: 100418-33-5 METHYLGELB
Endpoint summary
Administrative data
Description of key information
Guidelined oral and dermal study in rats. Under the experimental conditions employed the LD50 was calculated to be 1564 mg/kg bw and 1436 mg/kg bw in male and female rats respectively. The substance 2-((4-methyl-2-nitrophenyl)amino)ethanol was classified as acute toxicity (oral) category 4.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 436 mg/kg bw
- Quality of whole database:
- reliable without restriction
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- reliable without restriction
Additional information
Justification for classification or non-classification
LD50 (oral) is between 300 and 2000 mg/kg bw, Hydroxyethyl-2-nitro-p-toluidine is therefor to be classified according to (EG) Nr. 1272/2008 (CLP) as Acute Tox. 4 ( H302: Harmful if swallowed).
LD50 (dermal) is higher than 2000 mg/kg bw, Hydroxyethyl-2-nitro-p-toluidine is therefore not to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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