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EC number: 291-652-7
CAS number: 90459-11-3
In order to evaluate the skin
sensitising potential of the test item, an in vivo guinea pig
maximisation test (GPMT) was performed according to the OECD Guideline
406 (1981). A primary irritation experiment was performed in order to
determine the test concentrations of the main study. In the main study,
ten control animals (5 males, 5 females) were treated with the vehicle
alone (petrolatum oil) and 20 treatment animals (10 males, 10 females)
were treated with the test item. Treatments were firstly two inductions:
(i) an intradermal injection of 0.5 % test item; followed by (ii) an
epidermal application of 5 % test item. After two weeks, the animals
were subjected to two epidermal challenge applications separated by 24
hours using doses of 3 % in petrolatum.
No treatment or control animals were
positive for sensitisation, therefore, the sensitisation rate of the
test item was found to be 0 % to guinea pigs after intradermal and
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