D-Glucopyranose, oligomeric, C10-14-alkyl glycosides tartaric esters, sodium salt

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

(Q)SAR

Remarks:

The end point is covered by test carried out on another AlkylPolyGlucoside esters considering the similar structure and a number of cross experiments which shown a similar behaviour. A rationale is available on it

Adequacy of study:

key study

Study period:

From July 17 to 27, 2001

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Eucarol AGE SS (D-Glucopyranose, oligomeric, 6-(hydrogen 2-sulfobutanedioate), 1- (coco alkyl) ethers, sodium salts) was used as supporting substance due to the structural analogy. The alkylpolyglucoside has a carbon chain length range of C10-C14. It can be expected a similar structural features.

Justification for type of information:

The end point is covered by test carried out on another AlkylPolyGlucoside esters considering the similar structure and a number of cross experiments which shown a similar behaviour. A rationale is available on it

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Principles of method if other than guideline:

-

GLP compliance:

yes

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

D-Glucopyranose, oligomers, monosulfosuccinate, coco alkyl glycosides, sodium salts

EC Number:

500-331-5

EC Name:

D-Glucopyranose, oligomers, monosulfosuccinate, coco alkyl glycosides, sodium salts

Cas Number:

151911-53-4

IUPAC Name:

151911-53-4

Details on test material:

- Substance type: no longer polymer
- Physical state: viscous liquid, 55.5 % in water solution
- Lot/batch No.: 2001030007
- Expiration date of the lot/batch: 01/03/2003

Specific details on test material used for the study:

3 different test has been done, using different n-octanol/water volume ratios: 1:1 (v/v), 1:2 (v/v), 2:1 (v/v).

Results and discussion

Partition coefficient

Partition coefficient 1

Key result

Type:

Pow

Partition coefficient:

< 0.002

Temp.:

20 °C

Remarks on result:

other: pH not reported

Partition coefficient 2

Key result

Type:

log Pow

Partition coefficient:

-2.8

Temp.:

20 °C

Remarks on result:

other: pH not reported

Details on results:

D-Glucopyranose, oligomeric, 6-(hydrogen 2-sulfobutanedioate), 1- (coco alkyl) ethers, sodium salts is a complex mixture of different homologous, the chromatograms presented different peaks related to the test material, for the quantitative analyses a main component of the mixture was selected (peak at retention time = 2.05 minutes).
The height of the peak was measured in each chromatogram using the chromatographic software of the data station.

Applicant's summary and conclusion

Conclusions:

The n-octanol/water partition coefficient was determined at 20°C according to OECD 107.
D-Glucopyranose, oligomeric, 6-(hydrogen 2-sulfobutanedioate), 1- (coco alkyl) ethers, sodium salts has been found to be highly hydrophilic, since the analyte concentration in the n-octanol phases of the partition experiments were founded to be lower than the estimated limit of detection for the analytical method (50 ppm). In this case, the evaluation of the partition coefficient has been done considering the analytical limit of detection as the concentration limit for the n-octanol phase.

Partition coefficient value at 20°C : < 1.5 x 10^-3 (-2.8 as its decimal cologarithm).
This was the lowest value founded for all the series of partitioning tests.