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EC number: 249-008-8 | CAS number: 28407-37-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Appearance / physical state / colour:
The physical appearance of C.I Direct Blue 218 (CAS no. 28407-37-6) is observed to be a solid organic compound with Deep purple to dark blue amorphous powder in nature.
Melting point/ Freezing point:
Based on prediction done using MPBPVP v1.43, the melting point of chemical C.I Direct Blue 218 (CAS no. 28407-37-6) was estimated to be 350˚C.
Boiling point:
Based on prediction done using MPBPVP v1.43, the Boiling point of chemical C.I Direct Blue 218 (CAS no. 28407-37-6) was estimated to be 1560˚C.
Density:
The density of chemical C.I Direct Blue 218 (CAS no. 28407-37-6) was estimated to be 2.8 ± 0.1 g/cm3.
Particle size distribution (Granulometry):
The particle size distribution of C.I Direct Blue 218 (CAS no. 28407-37-6) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 147 micron to 52 micron.
Vapour pressure:
The estimated vapour pressure of the test substance C.I Direct Blue 218 (CAS no. 28407-37-6) at 25 deg C was 1.06E-39 Pa.
Partition coefficient:
Octanol water partition coefficient (Log Pow) of test chemical Copper,[tetrahydrogen-3,3'-[(3,3'-dihydroxy-4,4'-biphenylylene)bis(azo)]bis[5-amino-4-hydroxy-2,7-naphthalenedisulfonato](4-)]di-,tetrasodium salt (7CI) (CAS no. 28407-37-6) was determined to be -0.77 dimenionless. By considering log Pow value it is concluded that this test chemical is hydrophilc in nature and it is also supported by high water solubility of this test chemical.
Water solubility:
The water solubility of C.I Direct Blue 218 (CAS no. 28407-37-6) is determined to be in the range of 10000 - 50000 mg/L at 17 °C.
Surface tension:
In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. The C.I Direct Blue 218 (CAS no. 28407-37-6) is used as a laboratory chemical, Synthesis of substances, and as dye etc. For this use, surface activity is not an important property. Hence this study was considered for waiver.
Flash point:
The flash point of C.I Direct Blue 218 (CAS no. 28407-37-6) is determined to be greater than 360°C.
Autoflammability:
C.I Direct Blue 218 (CAS no. 28407-37-6) did not catch fire on being exposed to air at room temperature of 27°C pressure of 966 hPa. This indicates that C.I Direct Blue 218 (CAS no. 28407-37-6) is not auto-flammable.
Flammability:
C.I Direct Blue 218 (CAS no. 28407-37-6) does not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded that C.I Direct Blue 218 (CAS no. 28407-37-6) is not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thus C.I Direct Blue 218 (CAS no. 28407-37-6) was considered non-flammable for chemical safety assessment.
Explosiveness:
The study does not need to be conducted because the substance contains some chemical group associated with explosive properties which include oxygen, but the calculated oxygen balance is less than - 200, hence this study considered to be waiver.
Oxidising properties:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidizing properties and hence the classification procedure does not need to be applied.
Additional information
Appearance / physical state / colour:
Based on available data from authoritative databases, the physical appearance of C.I Direct Blue 218 (CAS no. 28407-37-6) is observed to be a solid organic compound with Deep purple to dark blue amorphous powder in nature.
Melting point/ Freezing point:
Based on the prediction done using the EPI Suite MPVPBP V1.43, the melting point of chemicalC.I Direct Blue 218 (CAS no. 28407-37-6)
was predicted.
The melting point of chemicalC.I Direct Blue 218 (CAS no. 28407-37-6)was estimated to be350˚C.
Boiling point:
Based on the prediction done using the EPI Suite MPVPBP V1.43, the Boiling point of chemicalC.I Direct Blue 218 (CAS no. 28407-37-6)
was predicted.
The boiling point of chemicalC.I Direct Blue 218 (CAS no. 28407-37-6)was estimated to be1560˚C.
Density:
Based on prediction done using ACD/I-Lab 2.0 and Scifinder, the density of chemical C.I Direct Blue 218 (CAS no. 28407-37-6)
was estimated to be 2.8 ± 0.1 g/cm3.
Particle size distribution (Granulometry):
The particle size distribution of C.I Direct Blue 218 (CAS no. 28407-37-6) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 147 micron to 52 micron.
Vapour pressure:
Modified Grain method (Mean of Antoine and Modified Grain methods) was used to estimate the vapour pressure of the test substance
C.I Direct Blue 218 (CAS no. 28407-37-6) using MPBPVP v1.43 of EPI SUITE.
The estimated vapour pressure of the test substance C.I Direct Blue 218 (CAS no. 28407-37-6) at 25 deg C was 1.06E-39 Pa.
Partition coefficient:
Octanol water partition coefficient (Log Pow) of test chemical Copper,[tetrahydrogen-3,3'-[(3,3'-dihydroxy-4,4'-biphenylylene)bis(azo)]bis[5-amino-4-hydroxy-2,7-naphthalenedisulfonato](4-)]di-,tetrasodium salt (7CI) (CAS no. 28407-37-6) was determined to be -0.77 dimenionless. By considering log Pow value it is concluded that this test chemical is hydrophilc in nature and it is also supported by high water solubility of this test chemical.
Water solubility:
Based on available data from authoritative databases, the water solubility of C.I Direct Blue 218 (CAS no. 28407-37-6) is determined to be in the range of 10000 - 50000 mg/L at 17 °C.
According to the obtained value the C.I Direct Blue 218 (CAS no. 28407-37-6) is considered to be very soluble in water.
Surface tension:
In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. The C.I Direct Blue 218 (CAS no. 28407-37-6) is used as a laboratory chemical, Synthesis of substances, and as dye etc. For this use, surface activity is not an important property. Hence this study was considered for waiver.
Flash point:
Based on available data from obtained report, the flash point of C.I Direct Blue 218 (CAS no. 28407-37-6) is determined to be greater than 360°C.
Hence on the basis of obtained value the C.I Direct Blue 218 (CAS no. 28407-37-6) is not classified as flammable.
Autoflammability:
C.I Direct Blue 218 (CAS no. 28407-37-6) did not catch fire on being exposed to air at room temperature of 27°C pressure of 966 hPa. This indicates that C.I Direct Blue 218 (CAS no. 28407-37-6) is not auto-flammable.
Flammability:
C.I Direct Blue 218 (CAS no. 28407-37-6) does not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded that C.I Direct Blue 218 (CAS no. 28407-37-6) is not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thus C.I Direct Blue 218 (CAS no. 28407-37-6) was considered non-flammable for chemical safety assessment.
Explosiveness:
The study does not need to be conducted because the substance contains some chemical group associated with explosive properties which include oxygen, but the calculated oxygen balance is less than - 200, hence this study considered to be waiver.
Oxidising properties:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidizing properties and hence the classification procedure does not need to be applied.
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