Registration Dossier
Registration Dossier
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EC number: 271-058-4 | CAS number: 68514-79-4 The complex combination of hydrocarbons obtained in a hydrofiner-powerformer process and boiling in a range of approximately 27°C to 210°C (80°F to 410°F).
Toxicological information
Toxicological Summary
Currently viewing:
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 286.4 mg/m³
- Most sensitive endpoint:
- neurotoxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC inter/intra species AF
- Overall assessment factor (AF):
- 9
- Dose descriptor starting point:
- LOAEC
- Value:
- 4 320 mg/m³
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 11 577.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
60 mins exposure adjusted for duration of work [60/15 {mins of work} x 6.7/10 {light work ventilation rate}]
- AF for dose response relationship:
- 3
- Justification:
- LOAEL adjusted to NOAEL using ECHA R.8 and ECETOC 'non-severe'.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not applicable, human study
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable human dataset (only data available)
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 837.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC inter/intraspecies AF
- Overall assessment factor (AF):
- 6
- Dose descriptor:
- NOAEC
- Value:
- 5 025 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Not required, starting point was a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Subchronic to chronic, ECHA R.8 value
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Effects at the membrane level such as chemical irritation are considered similar in all species
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable study available
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 066.67 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC inter/intraspecies AF
- Overall assessment factor (AF):
- 9
- Dose descriptor starting point:
- LOAEC
- Value:
- 9 600 mg/m³
- AF for dose response relationship:
- 3
- Justification:
- Starting point LOAEL adjusted to NOAEL (ECHA R.8 value)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not required; human study
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC intrapsecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable human dataset
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 152 mg/m³
- Most sensitive endpoint:
- neurotoxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating Concawe/ECETOC inter/intra species AF
- Overall assessment factor (AF):
- 15
- Dose descriptor starting point:
- LOAEC
- Value:
- 4 320 mg/m³
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 17 280 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Starting point 4320, 60 mins exposure adjusted for duration of work [60/15 {mins of work}] = 17280 mg/m3
- AF for dose response relationship:
- 3
- Justification:
- LOAEL adjusted to NOAEL using ECHA R.8 and ECETOC 'non-severe'.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not applicable, human study
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable study available
- AF for remaining uncertainties:
- 1
- Justification:
- Not requried
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 178.57 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: 'ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC intra/interspecies AF
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- NOAEC
- Value:
- 1 786 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Not required, starting point was a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Sub-chronic to chronic; ECHA R.8 value
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Effects at the membrane level such as chemical irritation are considered similar in all species
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC intrapsecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- reliable study available
- AF for remaining uncertainties:
- 1
- Justification:
- Not requried
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 640 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC intra/interspecies AF
- Overall assessment factor (AF):
- 15
- Dose descriptor starting point:
- LOAEC
- Value:
- 9 600 mg/m³
- AF for dose response relationship:
- 3
- Justification:
- Starting point LOAEL adjusted to NOAEL (ECHA R.8 value)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allomteric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not required, human study
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable human dataset
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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