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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
As a UVCB and natural complex substance, it is considered a constituents approach. This mother tincture contains about 65% of ethanol.
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
1974 test. No data
GLP compliance:
not specified
Remarks:
"Only nominal concentration measurements are available, However, fugacity data suggests low losses would be expected by evaporation. In addition there are no water quality data available and no GLP data." source UNEP publication
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
estuary fish
Test type:
static
Water media type:
freshwater
Total exposure duration:
96 h
Hardness:
40 to 50 mg/l CaCO3
Test temperature:
12°C +/- 1°C
Nominal and measured concentrations:
Method of calculating mean measured concentration: Only nominal concentrations used.
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
ca. 13 000 mg/L
Conc. based on:
not specified
Basis for effect:
no data
Remarks on result:
other: see page 99 of the UNEP publication
Validity criteria fulfilled:
yes
Conclusions:
With a LC50 (96h) for fish up to 10,000mg/l, ethanol is practically non toxic to fish.

Description of key information

On a constituent approach, the acute toxicity of Ledum palustre mother tincture (MT) to fish can be estimated using aquatic toxicity data from major constituents :

- ethanol : 65 % (+/- 5%)

- water : 35% (+/- 5%)

Ledum palustre MT fish toxicity is extrapolated from Ethanol fish toxicity data (worst case) :

 name of the component  % in the UVCB  LC50 (96h) Salmo gairdneri fish (mg/l)   LC50 (96h) Pimephales promelas fish (mg/l)  LC50 (96h) Alburnus alburnus (mg/l)    source
 ethanol  65  13000  13480  11000    UNEP publication
 water  35  no acute toxicity for fish  no acute toxicity fo fish  no acute toxicity for fish    
 Ledum palustre MT  100%  > 13000  > 13480  > 11000   Prediction value (according to point 4.1.3.4.2 and 4.1.3.5 of regulation EC 1272/2008)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
11 000 mg/L

Additional information

with a LC50 (96h) for fish between 16000mg/l and 20000 mg/l, Ledum palustre mother tincture is practically not harmful to fish and does not required any hazard statement regarding ecotoxicity (H400, H410, H411, H412, H413).