Ledum palustre, ext.

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

As a UVCB and natural complex substance, it is considered a constituents approach. This mother tincture contains about 65% of ethanol.

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

1974 test. No data

GLP compliance:

not specified

Remarks:

"Only nominal concentration measurements are available, However, fugacity data suggests low losses would be expected by evaporation. In addition there are no water quality data available and no GLP data." source UNEP publication

Analytical monitoring:

no

Vehicle:

not specified

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Details on test organisms:

estuary fish

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Hardness:

40 to 50 mg/l CaCO3

Test temperature:

12°C +/- 1°C

Nominal and measured concentrations:

Method of calculating mean measured concentration: Only nominal concentrations used.

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 13 000 mg/L

Conc. based on:

not specified

Basis for effect:

no data

Remarks on result:

other: see page 99 of the UNEP publication

Validity criteria fulfilled:

yes

Conclusions:

With a LC50 (96h) for fish up to 10,000mg/l, ethanol is practically non toxic to fish.

Description of key information

On a constituent approach, the acute toxicity of Ledum palustre mother tincture (MT) to fish can be estimated using aquatic toxicity data from major constituents :

- ethanol : 65 % (+/- 5%)

- water : 35% (+/- 5%)

Ledum palustre MT fish toxicity is extrapolated from Ethanol fish toxicity data (worst case) :

name of the component	% in the UVCB	LC50 (96h) Salmo gairdneri fish (mg/l)	LC50 (96h) Pimephales promelas fish (mg/l)	LC50 (96h) Alburnus alburnus (mg/l)		source
ethanol	65	13000	13480	11000		UNEP publication
water	35	no acute toxicity for fish	no acute toxicity fo fish	no acute toxicity for fish
Ledum palustre MT	100%	> 13000	> 13480	> 11000		Prediction value (according to point 4.1.3.4.2 and 4.1.3.5 of regulation EC 1272/2008)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

11 000 mg/L

Additional information

with a LC50 (96h) for fish between 16000mg/l and 20000 mg/l, Ledum palustre mother tincture is practically not harmful to fish and does not required any hazard statement regarding ecotoxicity (H400, H410, H411, H412, H413).