Tungsten hexachloride

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

other: Entry of the Agency for Toxic Substances and Disease Registry

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Toxicological profile for Tungsten

Author:

Keith S. et al.

Year:

2005

Bibliographic source:

Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1982

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Tungsten hexachloride

EC Number:

236-293-9

EC Name:

Tungsten hexachloride

Cas Number:

13283-01-7

Molecular formula:

Cl6W

IUPAC Name:

tungsten hexachloride

Test animals

Species:

rabbit

Administration / exposure

Details on dermal exposure:

Single application of a 5 % Tungsten hexachloride solution

Doses:

100, 200 and 1000 mg/kg bw

No. of animals per sex per dose:

2 rabbits per dose group

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

other: LOAEL

Effect level:

200 mg/kg bw

Effect levels 2

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 100 - < 200 mg/kg bw

Mortality:

In the high and mid dose all animals died after dosing. No deaths in the low dose group.

Any other information on results incl. tables

No information was located regarding mechanisms involved in absorption of tungsten through the skin. However, a report of death in rabbits following a single dermal application of a 5% tungsten chloride solution (Dow Chemical Company 1982) is evidence of absorption and systemic distribution of dermally applied tungsten.

Relatively little information is available concerning adverse effects in animals following acute-duration dermal exposure to tungsten. Contact dermatitis was reported in rabbits following dermal application of a 5% tungsten chloride solution in single doses ≥100 mg/kg; doses ≥200 mg/kg also resulted in death (Dow Chemical Company 1982). Instillation of a 5% tungsten chloride solution into the rabbit eye resulted in initial ocular irritation that resolved within 14 days postinstillation (Dow Chemical Company 1982).

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

No LD50 value can be determined based on this publication.

Executive summary:

A publication of the Dow Chemical Company (1982) on the toxicological properties of Tungsten hexachloride was citied in the report of the Agency for Toxic Substances and Disease Registry (2005) on the “Toxicological profile for Tungsten”. In this study two rabbits per dose group were dermally exposed to a 5 % solution of Tungsten hexachloride in absolute doses of 100, 200 and 1000 mg/kg body weight. While all animals died in the high and mid dose groups, the animals of the low dose developed contact dermatitis. An LD50 value can not be calculated based on these data. When instilled to the eye the 5% solution of Tungsten hexachloride caused temporary ocular irritation.