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Long-term toxicity to fish

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Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

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The aquatic toxicity toward fish under chronic conditions was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.