Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 918-205-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Negative in reverse gene mutation assay in bacteria (Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537 and TA 102 and Escherichia coli WP2uvrA, with and without metabolic activation (OECD 471/EU B.13/14, GLP, read-across from structural analogues)
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source substances and target substance have similar genetic toxicity because they share structural similarities with common functional groups. Source as well as target substances are all alkyltriphenylphosphonium halogen salts. The alkyltriphenylphosphonium moiety of source substances and target is almost identical, differing only in the length of the saturated linear alkyl chain (ethyl instead of n-butyl). The counterion of source 1 and target is identical - bromide, while source substance 2 has iodide as counterion.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source 1 Target
Name Ethyltriphenylfosfonium bromide n-Butyltriphenylphosphonium bromide
CAS 1530-32-1 1779-51-7
EC 216-223-3 217-219-4
Common functional group 1 counterion bromide counterion bromide
Common functional group 2 Triphenylphosphonium Triphenylphosphonium
Deviating functional group alkyl chain ethyl alkyl chain n-butyl
Purity Please refer to section ´Confidential details in general comparable to source substance
on test material´ of the respective source substance ID.
Source 2 Target
Name Ethyltriphenylphosphonium iodide n-Butyltriphenylphosphonium bromide
CAS 4736-60-1 1779-51-7
EC 225-245-2 217-219-4
Common functional group Triphenylphosphonium Triphenylphosphonium
Deviating functional group 1 saturated aliphatic chain ethyl saturated aliphatic chain n-butyl
Deviating functional group alkyl chain ethyl alkyl chain n-butyl
Purity Please refer to section ´Confidential details in general comparable to source substance
on test material´ of the respective source substance ID.
3. ANALOGUE APPROACH JUSTIFICATION
Read-across data used. The read-across hypothesis is based on the assumption that source substances and target do have comparable genetic toxicity. Source substances and target are all alkyltriphenylphosphonium halogen salts with an almost identical organic moiety, Ethyltriphenylphosphonium ion instead of n-Butyltriphenylphosphonium ion. Source 1 and target do have bromide as counterion, whereas source substance 2 has iodide as counterion.
However, all substances are soluble in water and also expected to be in physiological liquids. When dissolved, the organic moiety and the counterions act individually. Ethyltriphenylphosphonium iodide and - bromide were both negative in the bacterial reverse mutation assay, demonstrating that the counterions bromide and iodide of Alkyltriphenylphosphonium salts are not mutagenic. As the organic moiety of n-Butyltriphenylphosphonium differs from both source substances only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl chains are also not associated with genetic toxicity, this read-across is justified.
Both source entries are filled in as key studies as in addition to Salmonella typhimurium TA 98, TA 100, TA 1535 and TA 1537 source substance 1 was tested in E. coli WP2 uvr A and source substance 2 in Salmonella typhiumurium TA102. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Species / strain:
- other: all strains tested: S. typhimurium TA 98, 100, 102, 1535 and 1537 and E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- toxicity (reduction of the bacterial background lawn)
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Conclusions:
- Negative all strains tested: S. typhimurium TA 98, 100, 102, 1535 and 1537 and E. coli WP2 uvr A, with and without metabolic activation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Read-across data used. The read-across hypothesis is based on the assumption that source substances and target do have comparable genetic toxicity. Source substances and target are all alkyltriphenylphosphonium halogen salts with an almost identical organic moiety, Ethyltriphenylphosphonium ion instead of n-Butyltriphenylphosphonium ion. Source 1 and target do have bromide as counterion, whereas source substance 2 has iodide as counterion. However, all substances are soluble in water and also expected to be in physiological liquids. When dissolved, the organic moiety and the counterions act individually. Ethyltriphenylphosphonium iodide and - bromide were both negative in the bacterial reverse mutation assay, demonstrating that the counterions bromide and iodide of Alkyltriphenylphosphonium salts are not mutagenic. As the organic moiety of n-Butyltriphenylphosphonium differs from both source substances only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl chains are also not associated with genetic toxicity, this read-across is justified.
In in vitro bacterial reverse mutation assays according to OECD guideline 471 and EU method B.13/14, source substances Ethyltriphenylphosphonium iodide and Ethyltriphenylfosfonium bromide revealed no genetic toxicity. Because of this results, n-Butyltriphenylphosphonium bromide in all probability has also no genotoxic activity.
Justification for classification or non-classification
In in vitro bacterial reverse mutation assays according to OECD guideline 471 and EU method B.13/14, Ethyltriphenylphosphonium iodide and Ethyltriphenylfosfonium bromide revealed no genetic toxicity.
As the organic moieties of n-Butyltriphenylphosphonium bromide and Ethyltriphenylphosphonium iodide and Ethyltriphenylfosfonium bromide differ only in the length of the saturated alkyl chain - n-butyl instead of ethyl - and saturated alkyl chains are not associated with genetic toxicity as well as the counterions bromide and iodide, n-Butyltriphenylphosphonium bromide in all probability has also no genotoxic activity.
According to the criteria of REGULATION (EC) No 1272/2008, n-Butyltriphenylphosphonium bromide does not have to be classified and has no obligatory labeling requirement for mutagenicity. According to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations (2004), n-Butyltriphenylphosphonium bromide does not have to be classified for mutagenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.