Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Remarks:
- dissolution rate
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 19057:2017 „Continous Flow System“ (CFS)
- GLP compliance:
- no
- Type of method:
- other: Continous Flow System (CFS)
- Key result
- Remarks on result:
- other: The dissolution rate halftime ranges from 2.9 to 6 days.
- Details on results:
- The halftime of residual mass T1/2 is directly related to the dissolution rate k by k=ln2/(BET*T1/2). Here we compare the CSH nanoforms on their halftimes, because we anticipate less systematic errors by this descriptor. The halftimes were determined for the dissolution of Si and Ca as the main inorganic elements of CSH. However, only for Si the biological background is sufficiently low to detect the CSH dissolution, whereas the Ca background in the phagolysosomal simulant fluid at pH4.5 is nominally 8 mg/L,(Stefaniak, Guilmette et al. 2005) and the Ca dissolution from CSH nanoforms is not detectable on top of this background.
- Conclusions:
- Compared to the physiologically relevant timescales, which span a logarithmic range of hours to years, represented by benchmark materials of quick dissolution (e.g. ZnO NM110) to very slow dissolution (e.g. TiO2 NM105), the dissolution halftime is similar amongst all CSH nanoforms. The span ranges from 2.9 to 6 days.
Reference
Description of key information
Compared to the physiologically relevant timescales, which span a logarithmic range of hours to years, represented by benchmark materials of quick dissolution (e.g. ZnO NM110) to very slow dissolution (e.g. TiO2 NM105), the dissolution halftime is similar amongst all CSH nanoforms. The span ranges from 2.9 to 6 days.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
