Boron doped barium europium strontium silicate, orthorombic

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2012-04-26 to 2012-05-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Water solubility:

0.87 g/L

Conc. based on:

element (dissolved fraction)

Remarks:

Barium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

12.4

Remarks on result:

other: Concentration of Barium ion; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 0.79, 0.87 and 0.95 g/l Barium ion concentration. Relative standard deviation is 9.2%

Water solubility:

0.49 g/L

Conc. based on:

element (dissolved fraction)

Remarks:

Strontium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

12.4

Remarks on result:

other: Concentration of Strontium ion; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 0.44, 0.49 and 0.54 g/l Strontium Ion concentration. Relative standard deviation is 10.2%

Water solubility:

0.12 mg/L

Conc. based on:

act. ingr. (dissolved fraction)

Remarks:

Europium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

12.4

Remarks on result:

other: Concentration of Europium ion; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 0.098, 0.12 and 0.13 mg/l Europium Ion concentration. Relative standard deviation is 14.1%

Water solubility:

6.6 mg/L

Conc. based on:

element (dissolved fraction)

Remarks:

Boron

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

12.4

Remarks on result:

other: Concentration of boron; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 6.7, 6.5 and 6.6mg/l Boron concentration. Relative standard deviation is 1.5%

In a preliminary test different concentrations of test substance were checked for any undissolved particles

Table 1: Appearance of test mixtures

	amount of substance [mg]	amount of water [mL]	result
#1	122.1	0.1	undissolved
#2	122.1	0.5	undissolved
#3	122.1	1	undissolved
#4	122.1	2	undissolved
#5	122.1	10	undissolved
#6	63.4	100	undissolved
#7	10.5	100	undissolved
#8	11.1	500	undissolved
#9	3.9	500	undissolved

In all preliminary tests visual inspection shows that the mixture appears to be undissolved. Therefore solubility of test item <10mg/l. According to the guidelines for determination of water solubility, as main test the column elution method should be applied for compounds with solubility <10mg/L. For the test substance column elution method is not applicable: Coating of the support material (sea sand) is to be done by dissolving an excess of test article with an volatile organic solvent. As the test item may not be soluble in any organic solvent application of substance to support material cannot be performed. Therefore the flask method was applied.

A study was conducted according to OECD guideline 105 for determination of water solubility. The test was conducted in a GLP like setting and by the flask method. Concentration of cationic ingredients europium, strontium, barium were determined by ICP/OES and ICP/MS. Boron was determiend by ICPO/OES and ICP/MS also The test show that he test item itself has water solubility <10mg/L. Water solubility of europium residues is very low (0.12 mg/L), but release of barium (0.87g/L) and strontium is higher (0.49 g/L). Solubility of boron is low (0.0066 g/L). Measured pH value is 12.4

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2012-05-04 to 2012-05-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Water solubility:

0.54 g/L

Conc. based on:

element (dissolved fraction)

Remarks:

Barium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

11.8

Remarks on result:

other: Concentration of Barium ion; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 0.5, 0.57 and 0.55 g/l Barium ion concentration. Relative standard deviation is 6.7%

Water solubility:

0.58 g/L

Conc. based on:

element (dissolved fraction)

Remarks:

Strontium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

11.8

Remarks on result:

other: Concentration of Strontium ion; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 0.54, 0.61 and 0.59 g/l Strontium Ion concentration. Relative standard deviation is 6.2%

Water solubility:

0.071 mg/L

Conc. based on:

element (dissolved fraction)

Remarks:

Europium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

11.8

Remarks on result:

other: Conc. of europium ion; average of 3 experiments. Exp. data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in conc. of 0.061, 0.072 and 0.079 mg/L. Relative standard deviation is 12.8%. Limit of detection: 0.001 mg/L.

In a preliminary test different concentrations of test substance were checked for any undissolved particles

Table 1: Appearance of the test mixtures

	amount of substance [mg]	amount of water [mL]	result
#1	13.3	100	undissolved
#2	9.4	500	undissolved
#3	2.8	500	undissolved

In all preliminary tests visual inspection shows that the mixture appears to be undissolved. Therefore solubility of test item < 10mg/l.. According to the guidelines for determination of water solubility, as main test the column elution method should be applied for compounds with solubility 10mg/L. For the test substance column elution method is not applicable: Coating of the support material (sea sand) is to be done by dissolving an excess of test article with an volatile organic solvent. As the test item may not be soluble in any organic solvent application of substance to support material cannot be performed. Therefore the flask method was applied.

A study was conducted according to OECD guideline 105 for determination of water solubility. The test was conducted in a GLP like setting and by the flask method. Concentration of cationic ingredients europium, strontium, barium were determined by ICP/OES and ICP/MS. The test show that he test item itself has water solubility 10mg/L. Water solubility of europium residues is very low (0.071 mg/L), but release of barium (0.54g/L) and strontium is higher (0.58 g/L). Measured pH value is 11.8

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2012-05-03 to 2012-05-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Water solubility:

0.24 g/L

Conc. based on:

element (dissolved fraction)

Remarks:

Barium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

11.7

Remarks on result:

other: Concentration of Barium ion; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 0.22, 0.24 and 0.25 g/l Barium ion concentration. Relative standard deviation is 6.5%

Water solubility:

0.8 g/L

Conc. based on:

element (dissolved fraction)

Remarks:

Strontium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

11.7

Remarks on result:

other: Concentration of Strontium ion; average of 3 experiments. Experimental data refer to 24 hrs, 48 hrs, and 72 hrs stirring time of solution resulting in 0.72, 0.81 and 0.86 g/l Strontium Ion concentration. Relative standard deviation is 8.9%

Water solubility:

0.038 mg/L

Conc. based on:

element (dissolved fraction)

Remarks:

Europium

Loading of aqueous phase:

20 g/L

Temp.:

20 °C

pH:

11.7

Remarks on result:

other: Concentration of Europium ion; average of 3 experiments. Exp. data refer to 24, 48, 72 hrs stirring time of solution resulting in 0.044, 0.035 and 0.035 mg/l. Relative standard deviation is 13.7%. Limit of detection: 0.001 mg/l

In a preliminary test different concentrations of test substance were checked for any undissolved particles

	amount of substance [mg]	amount of water [mL]	result
#1	10.8	100	undissolved
#2	11.3	500	undissolved
#3	3.6	500	undissolved

In all preliminary tests visual inspection shows that the mixture appears to be undissolved. Therefore solubility of test item <10mg/l..

According to the guidelines for determination of water solubility, as main test the column elution method should be applied for compounds with solubility <10mg/L. For the test substance column elution method is not applicable: Coating of the support material (sea sand) is to be done by dissolving an excess of test article with an volatile organic solvent.

As the test item may not be soluble in any organic solvent application of substance to support material cannot be performed. Therefore the flask method was applied.

A study was conducted according to OECD guideline 105 for determination of water solubility. The test was conducted in a GLP like setting and by the flask method. Concentration of cationic ingredients europium, strontium, barium were determined by ICP/OES and ICP/MS. The test show that he test item itself has water solubility < 10mg/L. Water solubility of europium residues is very low (0.038 mg/L),but release of barium (0.24g/L) and strontium is higher (0.80 g/L). Measured pH value is 11.7

Description of key information

Three studies were conducted according to OECD guideline 105 for determination of water solubility. All tests were conducted in a GLP like setting and by the flask method. Concentration of cationic ingredients europium, strontium, barium were determined by ICP/OES and ICP/MS. In one test, boron concentrations were determined. All tests show that the test item itself has water solubility < 10mg/L. Water solubility of europium residues is very low (between 0.04 and 0.12 mg/L), boron concentration is low (0.007 g/L) exposure of barium (between 0.24g/L and 0.87 g/L) and strontium is higher (0.49 and 0.80 g/L). Measured pH values are between 11.7 and 12.4.