Registration Dossier
Registration Dossier
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EC number: 231-927-0 | CAS number: 7779-31-9
Endpoint summary
Administrative data
Description of key information
Reliable toxicity studies on freshwater algae, according to the OECD Test Guideline 201, were conducted on 3,3,5-TRIMETHYLCYCLOHEXYL METHACRYLATE (CAS 7779-31-9) as well as on its analogue 3,3,5-TRIMETHYLCYCLOHEXYL ACRYLATE (CAS 86178-38-3).
In the OECD 201 study with 3,3,5-TRIMETHYLCYCLOHEXYL METHACRYLATE (CAS 7779-31-9), the test item inhibited the growth rate of Pseudokirchneriella subcapitata up to 6.6% at saturation; therefore, an ErC50 could not be mathematically determined up to the limit of solubility. The ErC10 was equal to 1.05 mg/L (measured, TWA) and the NOECr was equal to 0.54 mg/L. The NOECr value is selected as a key value for chemical risk assessment.
In the OECD 201 study with the analogue substance 3,3,5-TRIMETHYLCYCLOHEXYL ACRYLATE (CAS 86178-38-3), the test item inhibited the growth rate of Pseudokirchneriella subcapitata up to 29.8% at saturation; therefore, an ErC50 could not be mathematically determined up to the limit of solubility. The ErC10 was equal to 0.43 mg/L (measured, geometric means).
In addition, reliable short-term toxicity studies on fish and daphnia (according to the OECD Test Guidelines 203 and 202, respectively) as well as an activated sludge respiration inhibition study (OECD TG 209) were performed on the analogue substance 3,3,5-TRIMETHYLCYCLOHEXYL ACRYLATE (CAS 86178-38-3). These data are used in in a read-across approach to fill data requirements for 3,3,5-TRIMETHYLCYCLOHEXYL METHACRYLATE (CAS 7779-31-9):
In an acute Danio rerio toxicity study, fish were exposed for 96h under semi-static conditions. The LC50 was determined to be 1.90 mg/L.
In an acute Daphnia magna toxicity study, cladocerans were exposed for 48h under semi-static conditions. The EC50 based on mobility was determined to be 14.43 mg/L.
In an activated sludge respiration inhibition study, microorganisms were exposed for 3h and no significant effects were observed up to the highest tested concentration. The NOEC based on respiration inhibition was equal to or greater than 1000 mg/L.
Additional information
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