Tetrahydrofurfuryl methacrylate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: comparable to guidelines/standards. No GLP.

Qualifier:

according to guideline

Guideline:

other: ASTM Comitee E-35 (Standard practice for conducting acute toxicity tests with fishes, macroinvertbrates and amphibians. 1980)

GLP compliance:

no

Analytical monitoring:

yes

Details on sampling:

no data

Vehicle:

no

Details on test solutions:

no data

Test organisms (species):

Pimephales promelas

Details on test organisms:

TEST ORGANISM
- Common name: Fathead Minnow
- Age at study initiation (mean and range, SD): 28 to 34 days
- Length at study initiation (length definition, mean, range and SD): 20.9 ± 2.0 mm
- Weight at study initiation (mean and range, SD): 0.134 ± 0.34 g
- Feeding during test no data

ACCLIMATION
no data

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Post exposure observation period:

no

Hardness:

45.3 ± 1.0 mg/L as CaCO3

Test temperature:

24.6 ± 0.4 °C

pH:

7.62 ± 0.12

Dissolved oxygen:

6.71 ± 0.57 mg/L

Salinity:

no data

Nominal and measured concentrations:

tested concentrations not specified in the publication

Details on test conditions:

TEST SYSTEM
- Test vessel: continuous flow modified Benoit mini-diluter system
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): no data
- No. of organisms per vessel: no data
- No. of vessels per concentration (replicates): no data
- Biomass loading rate: no data

TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Lake Superior Water, filtered through a sand/gravel filter

OTHER TEST CONDITIONS
- Adjustment of pH: no data
- Photoperiod: 16 h light/ 8 h dark
- Light intensity: no data

EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
daily observation: abnormal behavioural and morphological changes

TEST CONCENTRATIONS
no data

Reference substance (positive control):

not specified

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

34.7 mg/L

Nominal / measured:

not specified

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

60.9 mg/L

Remarks on result:

other: QSAR calculation

Details on results:

- Behavioural abnormalities: reduced spontaneous locomotor activity
- no permanent deformities
- probable MoA: narcosis

Results with reference substance (positive control):

no data

Reported statistics and error estimates:

no data

Validity criteria fulfilled:

not specified

Conclusions:

The 96 h-LC50 of THFMA in Pimephales promelas (Fathead Minnow) is reported to be 34.7 mg/L.

Executive summary:

In a 96-h acute toxicity study according to ASTM guideline "Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians" (1980), Pimephales promelas (Fathead Minnow) were exposed to THFMA (>97%) under flow through conditions. The concentrations tested were not specified in this publication.

The 96-h LC50 was 34.7 mg/L. 

Reduced spontaneous locomotor activity associated with a narcotic mode of action, but no permanent deformities were observed.

 

Results Synopsis

 

Test organism size/age (mean wet weight or length): Pimephales promelas, 28 – 34 days, 20.9 ± 2.0 mm

Test Type: Flowthrough

LC50:  34.7 mg/L

Endpoint(s) Effected: mortality

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Description of key information

LC50=34.7 mg/L; ASTM guideline "Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians” (flow through); no GLP

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

34.7 mg/L

Additional information

One study on acute toxicity of THFMA to fish is available, which is considered as reliable with restrictions (RL=2):

In a 96-h acute toxicity study according to ASTM guideline "Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians" (1980), Pimephales promelas (Fathead Minnow) were exposed to THFMA (>97%) under flow through conditions. The concentrations tested were not specified in this publication.Reduced spontaneous locomotor activity associated with a narcotic mode of action, but no permanent deformities were observed.

The 96-h LC50 was 34.7 mg/L.