Registration Dossier
Registration Dossier
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EC number: 233-343-1 | CAS number: 10124-56-8
Endpoint summary
Administrative data
Description of key information
Supporting study:
In adult CD-1 mice the acute oral LD50 of Sodium Hexametaphosphate was 3.7+/-0.17 g/kg.
Supporting study:
In adult Wistar rat the acute oral LD50 of Sodium Hexametaphosphate was 2.4+/-0.24 g/kg.
Supporting study:
The acute oral LD50 of Sodium Hexametaphosphate in female rats was 2900+/-258 mg/kg.
Supporting study:
Acute oral (gavage) LD50 of concentrated Sodium Hexametaphosphate in male rats was 2710 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- No information on the method.
- GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50=3.7 +/-0.17 g/kg
- Conclusions:
- In adult CD-1 mice the acute oral LD50 of Sodium Hexametaphosphate was 3.7+/-0.17 g/kg.
- Executive summary:
In adult CD-1 mice the acute oral LD50 of Sodium Hexametaphosphate was 3.7+/-0.17 g/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- No information on the method.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50=2.4 +/-0.24 g/kg
- Conclusions:
- In adult Wistar rat the acute oral LD50 of Sodium Hexametaphosphate was 2.4+/-0.24 g/kg.
- Executive summary:
In adult Wistar rat the acute oral LD50 of Sodium Hexametaphosphate was 2.4+/-0.24 g/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- No information on the method.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 900 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50=2900 +/-258 mg/kg
- Conclusions:
- The acute oral LD50 of Sodium Hexametaphosphate in female rats was 2900+/-258 mg/kg
- Executive summary:
The acute oral LD50 of Sodium Hexametaphosphate in female rats was 2900+/-258 mg/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
- Principles of method if other than guideline:
- No information on the method.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Route of administration:
- oral: gavage
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 710 mg/kg bw
- Based on:
- test mat.
- Conclusions:
- Acute oral (gavage) LD50 of concentrated Sodium Hexametaphosphate in male rats was 2710 mg/kg.
- Executive summary:
Acute oral (gavage) LD50 of concentrated Sodium Hexametaphosphate in male rats was 2710 mg/kg.
Referenceopen allclose all
Additional information
In adult CD-1 mice the acute oral LD50 of Sodium Hexametaphosphate was 3.7+/-0.17 g/kg.
Supporting study:
In adult Wistar rat the acute oral LD50 of Sodium Hexametaphosphate was 2.4+/-0.24 g/kg.
Supporting study:
The acute oral LD50 of Sodium Hexametaphosphate in female rats was 2900+/-258 mg/kg.
Supporting study:
Acute oral (gavage) LD50 of concentrated Sodium Hexametaphosphate in male rats was 2710 mg/kg.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
