Registration Dossier
Registration Dossier
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EC number: 219-168-3 | CAS number: 2379-79-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(1-aminoanthraquinon-2-yl)anthra[2,3-d]oxazole-5,10-dione
- EC Number:
- 219-168-3
- EC Name:
- 2-(1-aminoanthraquinon-2-yl)anthra[2,3-d]oxazole-5,10-dione
- Cas Number:
- 2379-79-5
- Molecular formula:
- C29H14N2O5
- IUPAC Name:
- 2-(1-aminoanthraquinon-2-yl)anthra[2,3-d]oxazole-5,10-dione
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hagemann, Germany
- Fasting period before study: 15 - 20 h prior to test start
- Diet (e.g. ad libitum): Herilan, ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5% CMC in water
- Details on oral exposure:
- single dose received by gavage
emulsion prepared with 6-35% CMC suspension
applied volume: 10 mL/kg - Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 10 rats (sex not specified)
- Control animals:
- no
- Details on study design:
- Observation period: 14 d after test substance administration
- Statistics:
- Determination of LD50: statistically if possible
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 10 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- act. ingr.
- Clinical signs:
- prone position, slight apathy, diarrhea, slight apathy, feces red discolored, dyspnea, animals cachectic
- Gross pathology:
- acute heart dilatation, congestion hyperemia, stomach dilatation, liquid gastric contents
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 (oral, gavage) in rats was determined at ca. 5000 mg/kg bw act. ingr. The substance is not classifiable according to CLP criteria.
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