7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one

Endpoint summary

Description of key information

Biodegradation in water:

Biodegradability of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) is predicted by using OECD QSAR tool box v. 3.4 using log Kow as primary descriptor. The test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one undergoes 18.11 % degradation by considering BOD as parameter  and Microorganisms as inoculum in 28 days. Based on percent biodegradability it is concluded that test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS No. 4133 -34 -0). If released in to the environment, 22.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.172 %), indicates that test chemical7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not persistent in sediment.

Biodegradation in soil:

The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS No. 4133 -34 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 77.0 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in soil is estimated to be 75.0 days (1800 hrs). Based on this half-life value of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .

Additional information

Biodegradation in water:

Predicted data for target compound 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) and supporting weight of evidence studies for its closest read across chemicals with log Kow as a primary descriptor were reviewed for the biodegradation endpoint which are summarized as below.

In first weight of evidence study the Biodegradability of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) was predicted by using OECD QSAR tool box v. 3.4 using log Kow as primary descriptor. The test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one undergoes 18.11 % degradation by considering BOD as parameter and Microorganisms as inoculums in 28 days. Based on percent biodegradability it is concluded that test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not readily biodegradable.

Another prediction was done by using the Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test compound 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical  7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is expected to be not readily biodegradable.

The supporting weight of evidence study done from authoritative database ( J check, 2017) in this study the Biodegradation experiment was carried out of read across chemical 1-Chloro-2,5-dimethoxybenzene (CAS no. 2100-42-7) by taking activated sludge as inoculums at 30 mg/L concentration . The initial concentration of read across chemical taken was 100 mg/L. Biodegradation was analyzed by using two parameters namely BOD and HPLC. The study design was of standard type. Percent biodegradation of read across chemical 1-Chloro-2,5-dimethoxybenzene was observed to be 0.0 % by both BOD and HPLC parameters in 28 days. Therefore it is concluded that read across chemical 1-Chloro-2,5-dimethoxybenzene is not readily biodegradable.

Similarly, another supporting weight of evidence study done from same source as mentioned above ( J check, 2017)in this study the Biodegradation experiment was carried out of read across chemical 1-chloro-2-[(1-chloropropan-2-yl)oxy]propane (CAS no.108-60-1) by taking activated sludge as inoculums at 30 mg/L concentration. The initial concentration of read across chemical taken was 100 mg/L. Biodegradation was analyzed by using three parameters namely BOD, TOC and GC. The study design was of improved type for volatile substance. Percent biodegradation of read across chemical 1-chloro-2-[(1-chloropropan-2-yl)oxy]propane was observed to be 0.0 % by BOD and GC parameters and 6.0 % by TOC parameter in 28 days. Therefore it is concluded that read across chemical 1-chloro-2-[(1-chloropropan-2-yl)oxy]propane is not readily biodegradable.

On the basis of above results for target chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS no. 4133 -34 -0) from EPI suite 2017 and OECD QSAR tool box v3.4, 2017 and for its read across substances (from authoritative database) the target chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one can be expected to be not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one(CAS No. 4133 -34 -0). If released in to the environment, 22.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.172 %), indicates that test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one is not persistent in sediment.

Biodegradation in soil:

The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one (CAS No. 4133 -34 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 77.0 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-onein soil is estimated to be 75.0 days (1800 hrs). Based on this half-life value of test chemical 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .