Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 690-928-8 | CAS number: 39992-90-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Oral ingestion of the test item may lead to absorption. In addition, there is limited potential absorption of IPDI-uron following dermal exposure. Inhalation is not considered to be a significant route of exposure. Bioaccumulation is not likely to occur based on the physical-chemical properties of IPDI-uron.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The IPDI is a solid with a molecular weight below 500 g/mol, water soluble (3.99 g/L) and a partition coefficient value between -1 and 4 (log Pow 1.81). Therefore, oral ingestion of the test item may lead to absorption. In addition, the aforementioned physico-chemical properties and the absence of local effects on the skin would suggest that there is limited potential absorption of IPDI-uron following dermal exposure. Inhalation is not considered to be a significant route of exposure based on the predicted vapour pressure (4.52E-7 Pa), low volatility and particle size (D50 > 300 µm).
Bioaccumulation is not likely to occur based on the physical-chemical properties of IPDI-uron. The octanol/water partition coefficient (log Pow 1.81) suggests limited fat solubility and that the substance is unlikely to accumulate in body fat. As described in ECHA guidance on information requirements and chemical safety assessment R.7c: Endpoint specific guidance (ECHA, June 2017), substances with a log Pow value less than or equal to 3 would be unlikely to accumulate with the intermittent repeated exposure patterns normally encountered in the workplace, but may accumulate if exposures are continuous.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
