Registration Dossier
Registration Dossier
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EC number: 226-237-1 | CAS number: 5332-24-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritive database
Data source
Reference
- Reference Type:
- other: Authoritive database
- Title:
- Skin irritation test for Quinoline (CAS no: 91-22-5)
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Skin irritation study of Quinoline (CAS no: 91-22-5) was conducted on clipped rabbits to determine its potential of causing skin irritation.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Quinoline
- Cas Number:
- 91-22-5
- Molecular formula:
- C9H7N
- IUPAC Name:
- Quinoline
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report):Quinoline
- Molecular formula:C9H7N
- Molecular weight :129.16 g/mol
- Substance type:Organic
- Physical state:Liquid
-Smiles: c12c(cccc1)nccc2
-InChI: 1S/C9H7N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-7H
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Quinoline
- Molecular formula:C9H7N
- Molecular weight :129.16 g/mol
- Substance type:Organic
- Physical state:Liquid
-Smiles: c12c(cccc1)nccc2
-InChI: 1S/C9H7N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-7H
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 10
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Slight reddening was observed in treated rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test material Quinoline (CAS no: 91-22-5) was considered to be mildly irritating to the rabbits skin.
- Executive summary:
Skin irritation study of Quinoline (CAS no: 91-22-5) was conducted on rabbits to determine its potential of causing skin irritation.
The chemical produced slight reddening after 24 hours when applied dermally. The resulted score was 4 out of maximum possible score of 10.
Therefore on the basis of observations, the chemical Quinoline (CAS no: 91-22-5)was considered to be mildly irritating to the rabbits skin.
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